ArticleThe Journal of infectious diseases2011
Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Family-based genome-wide association study of leprosy in Vietnam.PLoS pathogens · 2020Trial
- Identification of gene signatures and molecular mechanisms underlying the mutual exclusion between psoriasis and leprosy.Scientific reports · 2024Article
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- Psoriasis and Leprosy: An Arcane Relationship.Journal of inflammation research · 2023Article
- Offense and Defense in Granulomatous Inflammation Disease.Frontiers in cellular and infection microbiology · 2022Review
- Fine-Mapping of the Major Histocompatibility Complex Region Linked to Leprosy in Northern China.Frontiers in genetics · 2021Article
- The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions.PLoS pathogens · 2020Article
- Genetics of leprosy: today and beyond.Human genetics · 2020Review
- VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.PLoS neglected tropical diseases · 2018Article
- Human genetics of mycobacterial disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genetic Susceptibility to Leprosy-From Classic Immune-Related Candidate Genes to Hypothesis-Free, Whole Genome Approaches.Frontiers in immunology · 2018Review
- Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.PLoS genetics · 2017Article
- An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population.Arthritis research & therapy · 2015Article
- Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil.BMC infectious diseases · 2015Article
- CUBN and NEBL common variants in the chromosome 10p13 linkage region are associated with multibacillary leprosy in Vietnam.Human genetics · 2014Article
- Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.The Journal of infectious diseases · 2014Article
- Human genetics of tuberculosis: a long and winding road.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.American journal of human genetics · 2013Article
- Role of HLA, KIR, MICA, and cytokines genes in leprosy.BioMed research international · 2013Review
- PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.PLoS neglected tropical diseases · 2013Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 5 countries.
Funding
Abstract
Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10⁻⁹)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10⁻⁷ and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.