Evidence map›Paper›PMID 21459788›Full record

ArticleHaematologica2011

Genomic profiles of MALT lymphomas: variability across anatomical sites.

Ivo Kwee, Paola M V Rancoita, Andrea Rinaldi, Andrés J M Ferreri, Govind Bhagat, Randy D Gascoyne, Vincenzo Canzonieri, Gianluca Gaidano, Claudio Doglioni, Emanuele Zucca and 2 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 48 citations in OpenAlex.

  1. [Characteristics of Gastric Mucosa-associated Lymphoid Tissue Lymphoma in Korea].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024
    Review
  2. Genomic landscape of Epstein-Barr virus-positive extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Clinical aspects of malt lymphomas.Current hematologic malignancy reports · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Ivo KweeLaboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
Paola M V Rancoita
Andrea Rinaldi
Andrés J M Ferreri
Govind Bhagat
Randy D Gascoyne
Vincenzo Canzonieri
Gianluca Gaidano
Claudio Doglioni
Emanuele Zucca
Maurilio Ponzoni
Francesco Bertoni
Institute of Oncology Research · CHBC Cancer Agency · CAIstituti di Ricovero e Cura a Carattere Scientifico · ITNew York Hospital Queens · USUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MALT lymphomas present common features, but important differences are associated with involvement of specific anatomical sites, many likely contributing to the biology. To test the existence of genetic alterations specific for primary anatomical sites of involvement, genomic profiles obtained with high-density arrays were analyzed in 130 MALT lymphomas across a spectrum of anatomic sites. Trisomies 3 and 18 and del(6q23) occurred at a similar frequency. Instead, gains at 6p appeared significantly more common among MALT lymphomas involving the orbital adnexa. Gastric involvement showed a trend for a higher frequency of 8q gains. In conclusion, MALT lymphomas appear to bear a common set of recurrent unbalanced genomic alterations independent of the anatomical site. This differs from what has been observed for common chromosome translocations. Only a few alterations such as gains at 6p and, possibly, gains at 8q show preferential involvement at specific anatomical sites.

Indexed as

Gene Expression Regulation, NeoplasticGenetic VariationGenomicsChromosome AberrationsDNA Copy Number VariationsGene Expression ProfilingHumansLymphoma, B-Cell, Marginal ZoneOrgan Specificity

Identifiers

PMID21459788
PMCPMC3128228
OpenAlexW2026548922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.