ArticleJournal of neuroscience methods2011
Dependence of the paired motor unit analysis on motor unit discharge characteristics in the human tibialis anterior muscle.
Article in Journal of neuroscience methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Age-related differences in motor unit discharge rate modulation across contraction levels.GeroScience · 2026Article
- Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans.The Journal of physiology · 2026Article
- Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands.medRxiv : the preprint server for health sciences · 2026Article
- The modulation of human motoneuron discharge patterns with contraction force in resistance- and endurance-trained individuals.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Motor unit discharge properties are modestly influenced by menstrual cycle-related fluctuations in sex hormone concentrations.bioRxiv : the preprint server for biology · 2026Article
- Motor unit discharge properties of the vastii muscles and their modulation with contraction level depend on the knee-joint angle.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease.The European journal of neuroscience · 2025Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Immediate effect of local vibration on motor unit firing behavior and muscle strength in healthy young adult males.European journal of applied physiology · 2024Article
- Motoneuron persistent inward current contribution to increased torque responses to wide-pulse high-frequency neuromuscular electrical stimulation.European journal of applied physiology · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.The Journal of physiology · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.bioRxiv : the preprint server for biology · 2024Article
- Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.Journal of neurophysiology · 2023Article
- A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns.Journal of neural engineering · 2023Article
- Differences in psychological readiness for return to sport after anterior cruciate ligament injury is evident in thigh musculature motor unit characteristics.BMJ open sport & exercise medicine · 2023Article
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
- Neuromotor control associates with muscle weakness observed with McArdle sign of multiple sclerosis.Annals of clinical and translational neurology · 2022Article
- A computational approach for generating continuous estimates of motor unit discharge rates and visualizing population discharge characteristics.Journal of neural engineering · 2022Article
- Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults.GeroScience · 2021Article
- Estimates of persistent inward currents are reduced in upper limb motor units of older adults.The Journal of physiology · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The paired motor unit analysis provides in vivo estimates of the magnitude of persistent inward currents (PIC) in human motoneurons by quantifying changes in the firing rate (ΔF) of an earlier recruited (reference) motor unit at the time of recruitment and derecruitment of a later recruited (test) motor unit. This study assessed the variability of ΔF estimates, and quantified the dependence of ΔF on the discharge characteristics of the motor units selected for analysis. ΔF was calculated for 158 pairs of motor units recorded from nine healthy individuals during repeated submaximal contractions of the tibialis anterior muscle. The mean (SD) ΔF was 3.7 (2.5)pps (range -4.2 to 8.9 pps). The median absolute difference in ΔF for the same motor unit pair across trials was 1.8 pps, and the minimal detectable change in ΔF required to exceed measurement error was 4.8 pps. ΔF was positively related to the amount of discharge rate modulation in the reference motor unit (r² = 0.335; P<0.001), and inversely related to the rate of increase in discharge rate (r² = 0.125; P<0.001). A quadratic function provided the best fit for relations between ΔF and the time between recruitment of the reference and test motor units (r² = 0.229, P<0.001), the duration of test motor unit activity (r² = 0.110, P<0.001), and the recruitment threshold of the test motor unit (r² = 0.237, P<0.001). Physiological and methodological contributions to the variability in ΔF estimates of PIC magnitude are discussed, and selection criteria to reduce these sources of variability are suggested for the paired motor unit analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.