ArticleExperimental cell research2011
Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture.
Article in Experimental cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation.Journal of cell science · 2023Article
- Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks.Journal of mammary gland biology and neoplasia · 2020Review
- Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the absence of growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.Cellular and molecular life sciences : CMLS · 2017Review
- Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium.The Journal of cell biology · 2015Article
- A self-avoidance mechanism in patterning of the urinary collecting duct tree.BMC developmental biology · 2014Article
- Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype.Wiley interdisciplinary reviews. Membrane transport and signaling · 2014Article
- Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.PloS one · 2014Article
- Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.Molecular endocrinology (Baltimore, Md.) · 2013Article
- PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Developmental biology · 2013Article
- Dynamics of branched tissue assembly.Stem cell research & therapy · 2012Review
- Inhibitory morphogens and monopodial branching of the embryonic chicken lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Integrated morphodynamic signalling of the mammary gland.Nature reviews. Molecular cell biology · 2011Review
- SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number.Developmental cell · 2011Article
- An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity.Cell adhesion & migrationReview
- Review
Corrections and comments
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Authors and funding
3 authors.
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Abstract
During the branching morphogenesis process that builds epithelial trees, signaling from stimulatory and inhibitory growth factors is integrated to control branch initiation and extension into the surrounding stroma. Here, we examined the relative roles played by these stimulatory and inhibitory signals in the patterning of branch initiation and extension of model mammary epithelial tubules in culture. We found that although several growth factors could stimulate branching, they did not determine the sites at which new branches formed or the lengths to which branches extended. Instead, branch initiation and extension were defined by two separate signals downstream of the inhibitory morphogen, transforming growth factor (TGF)-β. Branch initiation was controlled by signaling through p38 mitogen-activated protein kinase, whereas branch extension was controlled by Smad-mediated induction of a second diffusible inhibitor, Wnt5a. These data suggest that mammary epithelial branching is patterned predominately by repulsive signaling, and that TGFβ activates multiple inhibitory pathways to refine the architecture of the tree.
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Registered trials
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