ReviewCurrent opinion in structural biology2011
Topological variation in the evolution of new reactions in functionally diverse enzyme superfamilies.
Review in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands.Antioxidants (Basel, Switzerland) · 2023Article
- Mechanisms of protein evolution.Protein science : a publication of the Protein Society · 2022Review
- Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis.Journal of the American Chemical Society · 2020Article
- Crystal Structures of L-DOPA Dioxygenase fromBiochemistry · 2019Article
- Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency.Biochimica et biophysica acta. Molecular basis of disease · 2019Article
- Informing Efforts to Develop Nitroreductase for Amine Production.Molecules (Basel, Switzerland) · 2018Article
- Cupincin: A Unique Protease Purified from Rice (Oryza sativa L.) Bran Is a New Member of the Cupin Superfamily.PloS one · 2016Article
- New insights about enzyme evolution from large scale studies of sequence and structure relationships.The Journal of biological chemistry · 2014Review
- The evolution of enzyme function in the isomerases.Current opinion in structural biology · 2014Review
- Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.PLoS biology · 2014Article
- Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.The Journal of biological chemistry · 2014Article
- Divergence and convergence in enzyme evolution.The Journal of biological chemistry · 2012Review
- Enzyme informatics.Current topics in medicinal chemistry · 2012Review
- Brain miffed by macrophage migration inhibitory factor.International journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In functionally diverse enzyme superfamilies (SFs), conserved structural and active site features reflect catalytic capabilities 'hard-wired' in each SF architecture. Overlaid on this foundation, evolutionary changes in active site machinery, structural topology and other aspects of structural organization and interactions support the emergence of new reactions, mechanisms, and substrate specificity. This review connects topological with functional variation in each of the haloalkanoic acid dehalogenase (HAD) and vicinal oxygen chelate fold (VOC) SFs and a set of redox-active thioredoxin (Trx)-fold SFs to illustrate a few of the varied themes nature has used to evolve new functions from a limited set of structural scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.