Trial reportJournal of the neurological sciences2011
Quantitative measures detect sensory and motor impairments in multiple sclerosis.
Trial report in Journal of the neurological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- The Relationship Between Brain MR Spectroscopy and Disability in Multiple Sclerosis: 20-Year Data from the U.S. Glatiramer Acetate Extension Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2017Trial
- Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis.Journal of visualized experiments : JoVE · 2016Trial
- Anxiety as a Psychological Modulator of Endogenous Pain Inhibition in Chronic Neck Pain: Implications for Precision Rehabilitation.Journal of pain research · 2026Article
- Examination of Proprioceptive Reliance During Backward Walking in Individuals With Multiple Sclerosis.Journal of neurologic physical therapy : JNPT · 2025Article
- Relationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study.Acta neurologica Belgica · 2025Observational
- Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers.Brain sciences · 2025Article
- Tract-specific analysis of diffusion MRI at 3T detects cervical spinal cord aberrations in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebellar volume measures may differentiate multiple sclerosis fallers from non-fallers.Research square · 2024Article
- Cerebellar Contributions to Motor and Cognitive Control in Multiple SclerosisArchives of physical medicine and rehabilitation · 2022Article
- Functional connectivity in the dorsal network of the cervical spinal cord is correlated with diffusion tensor imaging indices in relapsing-remitting multiple sclerosis.NeuroImage. Clinical · 2022Article
- A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design.Diagnostics (Basel, Switzerland) · 2021Article
- Five-year longitudinal changes in quantitative spinal cord MRI in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Combining Magnetization Transfer Ratio MRI and Quantitative Measures of Walking Improves the Identification of Fallers in MS.Brain sciences · 2020Article
- Force control during submaximal isometric contractions is associated with walking performance in persons with multiple sclerosis.Journal of neurophysiology · 2020Article
- Longitudinal assessment of hand function in individuals with multiple sclerosis.Multiple sclerosis and related disorders · 2019Article
- A two alternative forced choice method for assessing vibrotactile discrimination thresholds in the lower limb.Somatosensory & motor research · 2019Article
- Quantitative vibratory sensation measurement is related to sensory cortical thickness in MS.Annals of clinical and translational neurology · 2019Article
- Dynamic Balance Is Related to Physiological Impairments in Persons With Multiple Sclerosis.Archives of physical medicine and rehabilitation · 2018Article
- Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms.Temperature (Austin, Tex.) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSensory and motor dysfunction in multiple sclerosis (MS) is often assessed with rating scales which rely heavily on clinical judgment. Quantitative devices may be more precise than rating scales.
objectiveTo quantify lower extremity sensorimotor measures in individuals with MS, evaluate the extent to which they can detect functional systems impairments, and determine their relationship to global disability measures.
methodsWe tested 145 MS subjects and 58 controls. Vibration thresholds were quantified using a Vibratron-II device. Strength was quantified by a hand-held dynamometer. We also recorded Expanded Disability Status Scale (EDSS) and Timed 25-Foot Walk (T25FW). t-tests and Wilcoxon-rank sum were used to compare group data. Spearman correlations were used to assess relationships between each measure. We also used a step-wise linear regression model to determine how much the quantitative measures explain the variance in the respective functional systems scores (FSS).
resultsEDSS scores ranged from 0-7.5, mean disease duration was 10.4 ± 9.6 years, and 66% were female. In relapsing-remitting MS, but not progressive MS, poorer vibration sensation correlated with a worse EDSS score, whereas progressive groups' ankle/hip strength changed significantly with EDSS progression. Interestingly, not only did sensorimotor measures significantly correlate with global disability measures (i.e., EDSS), but they had improved sensitivity, as they detected impairments in up to 32% of MS subjects with normal sensory and pyramidal FSS.
conclusionsSensory and motor deficits in MS can be quantified using clinically accessible tools and distinguish differences among MS subtypes. We show that quantitative sensorimotor measures are more sensitive than FSS from the EDSS. These tools have the potential to be used as clinical outcome measures in practice and for future MS clinical trials of neurorehabilitative and neuroreparative interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.