ArticleBehavioural brain research2011
The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 80 citations in OpenAlex.
- EEG reveals that dextroamphetamine improves cognitive control through multiple processes in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Amphetamine improves mouse and human attention in the 5-choice continuous performance test.Neuropharmacology · 2018Trial
- Amphetamine Modestly Improves Conners' Continuous Performance Test Performance in Healthy Adults.Journal of the International Neuropsychological Society : JINS · 2018Trial
- Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors.The international journal of neuropsychopharmacology · 2017Trial
- Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.Neuropharmacology · 2017Trial
- Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.PloS one · 2012Trial
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Dopamine-mediated improvements of the step threshold task in Parkinson's disease: validation against clinical measures of motor and cognitive function.Frontiers in human neuroscience · 2025Article
- Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.Translational psychiatry · 2021Article
- Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a DPsychopharmacology · 2021Article
- Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention.Neuropharmacology · 2019Article
- The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species.Journal of neuroscience methods · 2017Review
- Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus.Scientific reports · 2017Article
- Neurophysiological Characterization of Attentional Performance Dysfunction in Schizophrenia Patients in a Reverse-Translated Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.Psychopharmacology · 2017Article
- Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.Neurobiology of aging · 2017Article
- The Five-Choice Continuous Performance Task (5C-CPT): A Cross-Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents.Current protocols in neuroscience · 2017Article
- Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges.Psychopharmacology · 2016Article
- Perseveration by NK1R-/- ('knockout') mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice Continuous Performance Test.Journal of psychopharmacology (Oxford, England) · 2016Article
- Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding.Behavioural brain research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice offers the opportunity to assess vigilance and two forms of impulsivity. Since reduced dopamine D4 receptor (DRD4) function is implicated in several disorders, DRD4 is a potential therapeutic target for cognition enhancement. We trained wildtype (WT), heterozygous (HT), and knockout (KO) mice of the murine Drd4 to perform the 5C-CPT under baseline and variable stimulus duration conditions. To dissect motor impulsivity (premature responding) from behavioral disinhibition (false alarms), we administered the 5-HT(2C) antagonist SB242084 during an extended inter-trial-interval session. We also examined the preattentive and exploratory profile of these mice in prepulse inhibition (PPI) and the Behavioral Pattern Monitor (BPM). Reduced Drd4 expression in HT mice, as confirmed by quantitative RT-PCR, resulted in response disinhibition and impaired 5C-CPT performance, while premature responding was unaffected. Conversely, SB242084 increased premature responding without affecting response inhibition or attentional measures. No genotypic differences were observed in PPI or BPM behavior. Thus, reduced Drd4 expression impairs attentional performance, but not other behaviors associated with neuropsychiatric disorders. Moreover, the use of signal and non-signal stimuli in the 5C-CPT enabled the differentiation of response disinhibition from motor impulsivity in a vigilance task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.