ArticleCurrent biology : CB2011
Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 67 citations in OpenAlex.
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- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins.Current biology : CB · 2022Article
- Quantifying cell transitions in C. elegans with data-fitted landscape models.PLoS computational biology · 2021Article
- An in silico analysis of robust but fragile gene regulation links enhancer length to robustness.PLoS computational biology · 2019Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Physiological Starvation PromotesG3 (Bethesda, Md.) · 2018Article
- Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018Review
- Article
- Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development.Development genes and evolution · 2017Article
- Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis.PLoS genetics · 2016Article
- Gap Gene Regulatory Dynamics Evolve along a Genotype Network.Molecular biology and evolution · 2016Article
- The developmental genetics of biological robustness.Annals of botany · 2016Review
- Pervasive robustness in biological systems.Nature reviews. Genetics · 2015Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBiological networks experience quantitative change in response to environmental and evolutionary variation. Computational modeling allows exploration of network parameter space corresponding to such variations. The intercellular signaling network underlying Caenorhabditis vulval development specifies three fates in a row of six precursor cells, yielding a quasi-invariant 3°3°2°1°2°3° cell fate pattern. Two seemingly conflicting verbal models of vulval precursor cell fate specification have been proposed: sequential induction by the EGF-MAP kinase and Notch pathways, or morphogen-based induction by the former.
resultsTo study the mechanistic and evolutionary system properties of this network, we combine experimental studies with computational modeling, using a model that keeps the network architecture constant but varies parameters. We first show that the Delta autocrine loop can play an essential role in 2° fate specification. With this autocrine loop, the same network topology can be quantitatively tuned to use in the six-cell-row morphogen-based or sequential patterning mechanisms, which may act singly, cooperatively, or redundantly. Moreover, different quantitative tunings of this same network can explain vulval patterning observed experimentally in C. elegans, C. briggsae, C. remanei, and C. brenneri. We experimentally validate model predictions, such as interspecific differences in isolated vulval precursor cell behavior and in spatial regulation of Notch activity.
conclusionsOur study illustrates how quantitative variation in the same network comprises developmental patterning modes that were previously considered qualitatively distinct and also accounts for evolution among closely related species.
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