ArticleThe New phytologist2011
Nitric oxide is required for an optimal establishment of the Medicago truncatula-Sinorhizobium meliloti symbiosis.
Article in The New phytologist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 134 citations in OpenAlex.
- Functional divergence and symbiotic significance of nitrate reductase isoforms in Medicago truncatula.Plant physiology · 2026Article
- Plant and aphid genotypes modulate legume rhizobium-induced defense against aphids.BMC plant biology · 2026Article
- HMolecular plant pathology · 2025Article
- Nitrogen-fixing symbiosis induces differential accumulation ofFrontiers in plant science · 2025Article
- Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile.Cell reports · 2024Article
- Dual RNA-Seq Analysis Pinpoints a Balanced Regulation between Symbiosis and Immunity inInternational journal of molecular sciences · 2023Article
- Nitric Oxide Detection Using a Chemical Trap Method for Applications in Bacterial Systems.Microorganisms · 2023Article
- The Key Roles of ROS and RNS as a Signaling Molecule in Plant-Microbe Interactions.Antioxidants (Basel, Switzerland) · 2023Review
- Free Radicals Mediated Redox Signaling in Plant Stress Tolerance.Life (Basel, Switzerland) · 2023Review
- Reactive Sulfur Species Produced by Cystathionine γ-lyase Function in the Establishment of Mesorhizobium loti-Lotus japonicus Symbiosis.Microbes and environments · 2023Article
- Signaling by reactive molecules and antioxidants in legume nodules.The New phytologist · 2022Review
- Nitric Oxide, Nitric Oxide Formers and Their Physiological Impacts in Bacteria.International journal of molecular sciences · 2022Review
- Exploring the Role of the NO-Detoxifying Enzyme HmpA in the Evolution of Domesticated Alfalfa Rhizobia.Microbial ecology · 2022Article
- Molecular interaction of charcoal rot pathogenesis in soybean: a complex interaction.Plant cell reports · 2021Review
- Structure and Development of the Legume-Rhizobial Symbiotic Interface in Infection Threads.Cells · 2021Review
- NO Network for Plant-Microbe Communication Underground: A Review.Frontiers in plant science · 2021Review
- Nitric Oxide Detoxification by Mesorhizobium loti Affects Root Nodule Symbiosis with Lotus japonicus.Microbes and environments · 2021Article
- Nitrogen and Phosphorus Signaling and Transport During Legume-Rhizobium Symbiosis.Frontiers in plant science · 2021Review
- Tyrosine Nitration of Flagellins: a Response of Sinorhizobium meliloti to Nitrosative Stress.Applied and environmental microbiology · 2020Article
- Aphid infestation differently affects the defences of nitrate-fed and nitrogen-fixingProceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a gaseous molecule that participates in numerous plant signalling pathways. It is involved in plant responses to pathogens and development processes such as seed germination, flowering and stomatal closure. Using a permeable NO-specific fluorescent probe and a bacterial reporter strain expressing the lacZ gene under the control of a NO-responsive promoter, we detected NO production in the first steps, during infection threads growth, of the Medicago truncatula-Sinorhizobium meliloti symbiotic interaction. Nitric oxide was also detected, by confocal microscopy, in nodule primordia. Depletion of NO caused by cPTIO (2-(4-carboxyphenyl)-4,4,5,5-tetramethyl imidazoline-1-oxyl-3-oxide), an NO scavenger, resulted in a significant delay in nodule appearance. The overexpression of a bacterial hmp gene, encoding a flavohaemoglobin able to scavenge NO, under the control of a nodule-specific promoter (pENOD20) in transgenic roots, led to the same phenotype. The NO scavenging resulting from these approaches provoked the downregulation of plant genes involved in nodule development, such as MtCRE1 and MtCCS52A. Furthermore, an Hmp-overexpressing S. meliloti mutant strain was found to be less competitive than the wild type in the nodulation process. Taken together, these results indicate that NO is required for an optimal establishment of the M. truncatula-S. meliloti symbiotic interaction.
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