ArticleBioconjugate chemistry2011
Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery.
Article in Bioconjugate chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- LiCl-driven direct synthesis of mono-protected esters from long-chain dicarboxylic fatty acids.RSC advances · 2025Article
- Charge-Conversion Strategies for Nucleic Acid Delivery.Advanced functional materials · 2021Article
- A Study of the Cellular Uptake of Magnetic Branched Amphiphilic Peptide Capsules.Molecular pharmaceutics · 2020Article
- Stimuli responsive charge-switchable lipids: Capture and release of nucleic acids.Chemistry and physics of lipids · 2016Article
- Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup.Soft matter · 2013Article
- Chemical oxidation of a redox-active, ferrocene-containing cationic lipid: influence on interactions with DNA and characterization in the context of cell transfection.Journal of colloid and interface science · 2012Article
- Charge-reversal lipids, peptide-based lipids, and nucleoside-based lipids for gene delivery.Accounts of chemical research · 2012Article
- Functional lipids and lipoplexes for improved gene delivery.Biochimie · 2012Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A series of charge-reversal lipids were synthesized that possess varying chain lengths and end functionalities. These lipids were designed to bind and then release DNA based on a change in electrostatic interaction with DNA. Specifically, a cleavable ester linkage is located at the ends of the hydrocarbon chains. The DNA release from the amphiphile was tuned by altering the length and position of the ester linkage in the hydrophobic chains of the lipids through the preparation of five new amphiphiles. The amphiphiles and corresponding lipoplexes were characterized by DSC, TEM, and X-ray, as well as evaluated for DNA binding and DNA transfection. For one specific charge-reversal lipid, stable lipoplexes of approximately 550 nm were formed, and with this amphiphile, effective in vitro DNA transfection activities was observed.
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Registered trials
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