ArticlePlant cell reports2011
Arabidopsis MAP kinase phosphatase 1 is phosphorylated and activated by its substrate AtMPK6.
Article in Plant cell reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Emerging Functions of Protein Tyrosine Phosphatases in Plants.International journal of molecular sciences · 2024Review
- CRISPR-targeted mutagenesis of mitogen-activated protein kinase phosphatase 1 improves both immunity and yield in wheat.Plant biotechnology journal · 2024Article
- Review
- Potato protein tyrosine phosphatase StPTP1a is activated by StMKK1 to negatively regulate plant immunity.Plant biotechnology journal · 2023Article
- MAP KINASE PHOSPHATASE1 promotes osmotolerance by suppressing PHYTOALEXIN DEFICIENT4-independent immunity.Plant physiology · 2022Article
- Plant salt response: Perception, signaling, and tolerance.Frontiers in plant science · 2022Review
- Understanding and Exploiting Post-Translational Modifications for Plant Disease Resistance.Biomolecules · 2021Review
- Article
- Expanding the Toolkit of Fluorescent Biosensors for Studying Mitogen Activated Protein Kinases in Plants.International journal of molecular sciences · 2020Article
- The Second Site Modifier,The Plant cell · 2019Article
- A Förster resonance energy transfer sensor for live-cell imaging of mitogen-activated protein kinase activity in Arabidopsis.The Plant journal : for cell and molecular biology · 2019Article
- MKP1 acts as a key modulator of stomatal development.Plant signaling & behavior · 2019Article
- Cellular Complexity in MAPK Signaling in Plants: Questions and Emerging Tools to Answer Them.Frontiers in plant science · 2018Review
- Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets ofMolecular & cellular proteomics : MCP · 2018Article
- Nuclear Signaling of Plant MAPKs.Frontiers in plant science · 2018Review
- Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling.Frontiers in plant science · 2018Review
- Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria.Plant physiology · 2017Article
- Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein.Plant physiology · 2017Article
- Cellular reprogramming through mitogen-activated protein kinases.Frontiers in plant science · 2015Review
- Functional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences.Genome biology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis MAP kinase phosphatase 1 (AtMKP1) is a member of the mitogen-activated protein kinase (MPK) phosphatase family, which negatively regulates AtMPKs. We have previously shown that AtMKP1 is regulated by calmodulin (CaM). Here, we examined the phosphorylation of AtMKP1 by its substrate AtMPK6. Intriguingly, AtMKP1 was phosphorylated by AtMPK6, one of AtMKP1 substrates. Four phosphorylation sites were identified by phosphoamino acid analysis, TiO(2) chromatography and mass spectrometric analysis. Site-directed mutation of these residues in AtMKP1 abolished the phosphorylation by AtMPK6. In addition, AtMKP1 interacted with AtMPK6 as demonstrated by the yeast two-hybrid system. Finally, the phosphatase activity of AtMKP1 increased approximately twofold following phosphorylation by AtMPK6. By in-gel kinase assays, we showed that AtMKP1 could be rapidly phosphorylated by AtMPK6 in plants. Our results suggest that the catalytic activity of AtMKP1 in plants can be regulated not only by Ca(2+)/CaM, but also by its physiological substrate, AtMPK6.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.