ArticleIntensive care medicine2011
Optimisation of positive end-expiratory pressure by forced oscillation technique in a lavage model of acute lung injury.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01506284 (Assessment of Airways Mechanical Properties by Forced Oscillatory Technique), which is not on this map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Airways Mechanical Properties by Forced Oscillatory Technique (FOT) and Laser Interferometry (LIR) During Anesthesia.
Who cites it
17 citing papers in PubMed.
- Tracking respiratory mechanics around natural breathing rates via variable ventilation.Scientific reports · 2020Trial
- Combining lung ultrasound and oscillatory mechanics for assessing lung disease in very preterm infants.Pediatric research · 2024Observational
- Clinical significance and applications of oscillometry.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Different Methods to Improve the Monitoring of Noninvasive Respiratory Support of Patients with Severe Pneumonia/ARDS Due to COVID-19: An Update.Journal of clinical medicine · 2022Review
- Update on ventilatory management of extremely preterm infants-A Neonatal Intensive Care Unit perspective.Paediatric anaesthesia · 2022Review
- Imaging the Injured Lung: Mechanisms of Action and Clinical Use.Anesthesiology · 2019Review
- Role of Lung Function Monitoring by the Forced Oscillation Technique for Tailoring Ventilation and Weaning in Neonatal ECMO: New Insights From a Case Report.Frontiers in pediatrics · 2018Article
- Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.Pediatric research · 2017Article
- Trends in mechanical ventilation: are we ventilating our patients in the best possible way?Breathe (Sheffield, England) · 2017Review
- Intratidal Overdistention and Derecruitment in the Injured Lung: A Simulation Study.IEEE transactions on bio-medical engineering · 2017Article
- An Official American Thoracic Society/European Respiratory Society Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units.Annals of the American Thoracic Society · 2016Review
- Year in review 2012: Critical Care--Respirology.Critical care (London, England) · 2013Review
- Relationship between respiratory impedance and positive end-expiratory pressure in mechanically ventilated neonates.Intensive care medicine · 2013Article
- Optimizing positive end-expiratory pressure by oscillatory mechanics minimizes tidal recruitment and distension: an experimental study in a lavage model of lung injury.Critical care (London, England) · 2012Article
- Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.Intensive care medicine · 2012Article
- Forced oscillation technique: an alternative tool to define the optimal PEEP?Intensive care medicine · 2011Article
- Positive end-expiratory pressure optimization with forced oscillation technique reduces ventilator induced lung injury: a controlled experimental study in pigs with saline lavage lung injury.Critical care (London, England) · 2011Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation.
methodsWe studied seven pigs in which lung injury was induced by broncho-alveolar lavage. The animals were ventilated in volume control mode with a tidal volume of 6 ml/kg. Forced oscillations were superimposed on the ventilation waveform for the assessment of respiratory mechanics. PEEP was increased from 0 to 24 cmH(2)O in steps of 4 cmH(2)O and subsequently decreased from 24 to 0 in steps of 2 cmH(2)O. At each 8-min step, a CT scan was acquired during an end-expiratory hold, and blood gas analysis was performed. C(X5) was monitored continuously, and data relative to the expiratory hold were selected and averaged for comparison with CT and oxygenation.
resultsOpen lung PEEP (PEEP(ol)) was defined as the level of PEEP corresponding to the maximum value of C(X5) on the decremental limb of the PEEP trial. PEEP(ol) was on average 13.4 (± 1.0) cmH(2)O. For higher levels of PEEP, there were no significant changes in the amount of non-aerated tissue (V(tissNA)%). In contrast, when PEEP was reduced below PEEP(ol), V(tissNA)% dramatically increased. PEEP(ol) was able to prevent a 5% drop in V(tissNA)% with 100% sensitivity and 92% specificity. At PEEP(ol) V(tissNA)% was significantly lower than at the corresponding PEEP level on the incremental limb.
conclusionsThe assessment of C(X5) allowed the definition of PEEP(ol) to be in agreement with CT data. Thus, FOT measurements of C(X5) may provide a non-invasive bedside tool for PEEP titration.
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