ArticleAge (Dordrecht, Netherlands)2012
Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age.
Article in Age (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines.PLoS biology · 2019Article
- New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach.Oxidative medicine and cellular longevity · 2019Review
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Motivations for Botanical Use by Socioeconomically Diverse, Urban Adults: Does Evidence Support Motivation?Journal of alternative and complementary medicine (New York, N.Y.) · 2017Article
- Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Can consumption of antioxidant rich mushrooms extend longevity?: antioxidant activity of Pleurotus spp. and its effects on Mexican fruit flies' (Anastrepha ludens) longevity.Age (Dordrecht, Netherlands) · 2015Article
- Nutraceuticals for geriatrics.Journal of traditional and complementary medicine · 2015Review
- Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.Pharmacological reviews · 2014Review
- Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans.Age (Dordrecht, Netherlands) · 2014Article
- Article
- A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies.Age (Dordrecht, Netherlands) · 2013Article
- The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster.Age (Dordrecht, Netherlands) · 2013Article
- Nutraceutical interventions for promoting healthy aging in invertebrate models.Oxidative medicine and cellular longevity · 2012Review
- Effects of long-term cranberry supplementation on endocrine pancreas in aging rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Botanicals rich with phytochemicals have numerous health benefits. Dietary restriction (DR) extends lifespan in diverse species. We previously demonstrated that an oregano-cranberry (OC) mixture can promote longevity in the Mexican Fruit fly (Mexfly, Anastrepha ludens Loew). However, little is known about the interaction between botanicals and DR, and the age-dependent effect of botanicals on lifespan and reproduction. Here we investigated these issues by feeding Mexflies a full or DR diet supplemented with or without 2% OC. Lifespan and daily egg production of individual flies were recorded. The effect of short-term OC supplementation was evaluated by implementing the supplementation at three age intervals-young, middle, and old age. We found that OC increased lifespan of Mexflies on the full or DR diet when compared to their respective controls. OC increased reproduction of females on the full diet and, to a lesser extent, on the DR diet. Short-term OC supplementation was not sufficient to extend lifespan for males at all three age intervals nor for females at young and old age intervals. However, OC supplementation at the middle age interval was sufficient to extend lifespan in females, while only OC supplementation at the young age interval increased reproduction in females. Our findings suggest that OC extends lifespan and promotes reproduction partly through DR-independent pathways, and short-term supplementation have varied impact on longevity and reproduction. This also suggests a positive interaction between non-genetic interventions in promoting longevity and provides guidance for using botanicals as aging interventions in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.