ArticlePLoS genetics2011
Interactions among Polycomb domains are guided by chromosome architecture.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed.
- Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression.The FEBS journal · 2026Review
- Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag.Molecular cell · 2025Article
- The scales, mechanisms, and dynamics of the genome architecture.Science advances · 2024Review
- Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite.EMBO reports · 2023Article
- Decoding enhancer complexity with machine learning and high-throughput discovery.Genome biology · 2023Review
- A gene regulatory network for neural induction.eLife · 2023Article
- The Transcriptional RegulatorBiomedicines · 2022Article
- Application of the 3C Method to Study the Developmental Genes inFrontiers in genetics · 2022Article
- Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo.Developmental cell · 2021Article
- Principles of 3D compartmentalization of the human genome.Cell reports · 2021Article
- INT-Hi-C reveals distinct chromatin architecture in endosperm and leaf tissues of Arabidopsis.Nucleic acids research · 2021Article
- Local rewiring of genome-nuclear lamina interactions by transcription.The EMBO journal · 2020Article
- Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.Nature genetics · 2020Article
- Chromosome conformation capture that detects novel cis- and trans-interactions in budding yeast.Methods (San Diego, Calif.) · 2020Article
- Chromosome Territorial Organization Drives Efficient Protein Complex Formation: A Hypothesis.The Yale journal of biology and medicine · 2019Review
- PRC2 is high maintenance.Genes & development · 2019Review
- Chromosome territories and the global regulation of the genome.Genes, chromosomes & cancer · 2019Review
- The role of transcription in shaping the spatial organization of the genome.Nature reviews. Molecular cell biology · 2019Review
- Large-scale 3D chromatin reconstruction from chromosomal contacts.BMC genomics · 2019Article
- Chromatin folding and nuclear architecture: PRC1 function in 3D.Current opinion in genetics & development · 2019Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal interactions in Drosophila melanogaster larval brain tissue. Our results demonstrate that PcG target genes interact extensively with each other in nuclear space. These interactions are highly specific for PcG target genes, because non-target genes with either low or high expression show distinct interactions. Notably, interactions are mostly limited to genes on the same chromosome arm, and we demonstrate that a topological rather than a sequence-based mechanism is responsible for this constraint. Our results demonstrate that many interactions among PcG target genes exist and that these interactions are guided by overall chromosome architecture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.