ArticleWorld journal of gastroenterology2011
Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 12 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 12 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The pertinence of gastric cancer and interleukin 10-819 single nucleotide polymorphisms: a meta-analysis and systematic review.BMC gastroenterology · 2024Pooled it
- ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019Pooled it
- Relationship Between Interleukin-10 Gene C-819T Polymorphism and Gastric Cancer Risk: Insights From a Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Pooled it
- The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis.Scientific reports · 2014Pooled it
- The interleukin 10 -819C/T polymorphism and cancer risk: a HuGE review and meta-analysis of 73 studies including 15,942 cases and 22,336 controls.Omics : a journal of integrative biology · 2013Pooled it
- Pooled it
- The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.Familial cancer · 2012Pooled it
- Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case-control studies.Molecular biology reports · 2012Pooled it
- A meta-analysis of interleukin-10-1082 promoter polymorphism associated with gastric cancer risk.DNA and cell biology · 2012Pooled it
- Pooled it
- A meta-analysis of interleukin-10 -592 promoter polymorphism associated with gastric cancer risk.PloS one · 2012Pooled it
- Association ofCanadian journal of gastroenterology & hepatology · 2021Review
- Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.Bosnian journal of basic medical sciences · 2020Article
- Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population.BMC cancer · 2019Article
- Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.BMC gastroenterology · 2018Article
- Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis.Oncotarget · 2017Article
- The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients.BMC genetics · 2015Article
- Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review).Oncology letters · 2015Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients.
methodsThe IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients.
resultsThe IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test.
conclusionIL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.
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