ArticleMedical science monitor : international medical journal of experimental and clinical research2011
A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- The Effect of the Concurrent Use of Angiotensin-Converting Enzyme Inhibitors or Receptor Blockers on Toxicity and Outcomes in Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents.International journal of radiation biology · 2025Article
- Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis.Materials today. Bio · 2022Article
- Hydrogen Gas in Cancer Treatment.Frontiers in oncology · 2019Review
- Local generation of hydrogen for enhanced photothermal therapy.Nature communications · 2018Article
- Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.Oxidative medicine and cellular longevity · 2016Article
- A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.Medical gas research · 2014Review
- Opportunities for rehabilitation of patients with radiation fibrosis syndrome.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2014Review
- Hydrogen therapy may be an effective and specific novel treatment for acute graft-versus-host disease (GVHD).Journal of cellular and molecular medicine · 2013Article
- Hydrogen as a new class of radioprotective agent.International journal of biological sciences · 2013Review
- Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.Oxidative medicine and cellular longevity · 2012Review
- Guidelines for the selection of hydrogen gas inhalers based on hydrogen explosion accidents.Medical gas researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).<br />
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.