ArticlePhysics in medicine and biology2011
The effects of object activity distribution on multiplexing multi-pinhole SPECT.
Article in Physics in medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Examination of aperture layout designs for an adaptive-stationary multi-pinhole brain-dedicated SPECT system.Medical physics · 2025Article
- Correction of multiplexing artefacts in multi-pinhole SPECT through temporal shuttering, de-multiplexing of projections, and alternating reconstruction.Physics in medicine and biology · 2024Article
- Multi-pinhole collimator design in different numbers of projections for brain SPECT.Frontiers in medicine · 2023Article
- Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study.Sensors (Basel, Switzerland) · 2021Article
- The clinical utilities of multi-pinhole single photon emission computed tomography.Quantitative imaging in medicine and surgery · 2020Review
- High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study.Scientific reports · 2019Article
- Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator.IEEE transactions on nuclear science · 2016Article
- Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging.Medical physics · 2015Review
- Reducing multiplexing artifacts in multi-pinhole SPECT with a stacked silicon-germanium system: a simulation study.IEEE transactions on medical imaging · 2014Article
- Performance evaluation of small-animal multipinhole μSPECT scanners for mouse imaging.European journal of nuclear medicine and molecular imaging · 2013Article
- The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT.IEEE transactions on nuclear science · 2013Article
- Advances in preclinical SPECT instrumentation.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Article
- Advances in pinhole and multi-pinhole collimators for single photon emission computed tomography imaging.World journal of nuclear medicineReview
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Authors and funding
3 authors.
Funding
Abstract
We aim to study the effects of activity distribution for multiplexing multi-pinhole (MPH) SPECT. Three digital phantoms, including a hot rod, a cold rod and a cold sphere phantom, were used. Different degrees of multiplexing were obtained by (i) adjusting the MPH pattern for the same 4-pinhole collimator (scheme 1) and (ii) increasing the number of pinholes (scheme 2). Noise-free and noisy projections were generated using a 3D analytical MPH projector based on the same acquisition time. Projections were reconstructed using OS-EM without resolution recovery. Normalized mean-square-error (NMSE), noise, image profiles and signal-to-background ratios (SBR) were assessed. For the hot rod phantom, the NMSE-noise trade-offs slightly improves for multiplexing designs in scheme 2. Substantial artifacts were observed and the NMSE-noise trade-offs slightly worsened for multiplexing designs for the cold phantoms. Resolutions slightly degraded for higher degrees of multiplexing (∼39-65%) for the cold rod phantom. For the cold sphere phantom, image profiles showed non-multiplexing designs better emulated the phantom, while ∼20% multiplexing performs similarly as compared to non-multiplexing in SBR. Our results indicate that multiplexing can help for sparse objects but leads to a significant image degradation in non-sparse distributions. Since many tracers are not highly specific, and the gain of detection efficiency by allowing multiplexing is fairly offset by image degradations, multiplexing needs to be kept to a minimum for optimum MPH collimator designs.
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