ArticleThe Journal of biological chemistry2011
Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
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- Protein-Protein Interactions of Odorant and G Protein-Coupled Receptors: A BRET Analysis Approach.Methods in molecular biology (Clifton, N.J.) · 2025Article
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- The Role of Endogenous Metal Nanoparticles in Biological Systems.Biomolecules · 2021Review
- The Structural Properties of Odorants Modulate Their Association to Human Odorant Binding Protein.Biomolecules · 2021Article
- Immobilization of Olfactory Receptors Carried by Nanosomes onto a Gold Sensor Surface.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant.Scientific reports · 2020Article
- The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?Frontiers in pharmacology · 2019Review
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.Basic research in cardiology · 2017Article
- Structurally related odorant ligands of the olfactory receptor OR51E2 differentially promote metastasis emergence and tumor growth.Oncotarget · 2017Article
- Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.Cellular and molecular life sciences : CMLS · 2016Review
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- Early survival factor deprivation in the olfactory epithelium enhances activity-driven survival.Frontiers in cellular neuroscience · 2013Article
- Modeling of mammalian olfactory receptors and docking of odorants.Biophysical reviews · 2012Review
- TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G-protein-coupled receptor homo-oligomerization has been increasingly reported. However, little is known regarding the relationship between activation of the receptor and its association/conformational states. The mammalian olfactory receptors (ORs) belong to the G protein-coupled receptor superfamily. In this study, the homo-oligomerization status of the human OR1740 receptor and its involvement in receptor activation upon odorant ligand binding were addressed by co-immunoprecipitation and bioluminescence resonance energy transfer approaches using crude membranes or membranes from different cellular compartments. For the first time, our data clearly show that mammalian ORs constitutively self-associate into homodimers at the plasma membrane level. This study also demonstrates that ligand binding mediates a conformational change and promotes an inactive state of the OR dimers at high ligand concentrations. These findings support and validate our previously proposed model of OR activation/inactivation based on the tripartite odorant-binding protein-odorant-OR partnership.
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