ArticleThe Journal of biological chemistry2011
Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models.bioRxiv : the preprint server for biology · 2026Article
- Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis.Structure (London, England : 1993) · 2026Article
- A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation.Nucleic acids research · 2023Article
- New DNA Plasmid Model for Studying DNA Mismatch Repair Response to the G4 Structure.International journal of molecular sciences · 2023Article
- The selection process of licensing a DNA mismatch for repair.Nature structural & molecular biology · 2021Article
- Sharp kinking of a coiled-coil in MutS allows DNA binding and release.Nucleic acids research · 2019Article
- Article
- The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences.DNA repair · 2018Article
- Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein.The journal of physical chemistry. B · 2017Article
- Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair.DNA repair · 2016Review
- The sliding clamp tethers the endonuclease domain of MutL to DNA.Nucleic acids research · 2015Article
- New insights into the mechanism of DNA mismatch repair.Chromosoma · 2015Review
- Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair.DNA repair · 2015Article
- Exonuclease 1-dependent and independent mismatch repair.DNA repair · 2015Review
- Article
- Is thymidine glycol containing DNA a substrate of E. coli DNA mismatch repair system?PloS one · 2014Article
- Slow conformational changes in MutS and DNA direct ordered transitions between mismatch search, recognition and signaling of DNA repair.Journal of molecular biology · 2013Article
- DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.Nucleic acids research · 2013Article
- Modern aspects of the structural and functional organization of the DNA mismatch repair system.Acta naturae · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ternary complex comprising MutS, MutL, and DNA is a key intermediate in DNA mismatch repair. We used chemical cross-linking and fluorescence resonance energy transfer (FRET) to study the interaction between MutS and MutL and to shed light onto the structure of this complex. Via chemical cross-linking, we could stabilize this dynamic complex and identify the structural features of key events in DNA mismatch repair. We could show that in the complex between MutS and MutL the mismatch-binding and connector domains of MutS are in proximity to the N-terminal ATPase domain of MutL. The DNA- and nucleotide-dependent complex formation could be monitored by FRET using single cysteine variants labeled in the connector domain of MutS and the transducer domain of MutL, respectively. In addition, we could trap MutS after an ATP-induced conformational change by an intramolecular cross-link between Cys-93 of the mismatch-binding domain and Cys-239 of the connector domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.