ArticleThe Journal of biological chemistry2011
The catalytic architecture of leukotriene C4 synthase with two arginine residues.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Structure Bioinformatics of Six Human Integral Transmembrane Enzymes and their AlphaFold3 Predicted Water-Soluble QTY Analogs: Insights into FACE1 and STEA4 Binding Mechanisms.Pharmaceutical research · 2025Article
- Development and Validation of Methodologies for the Identification of Specialized Pro-Resolving Lipid Mediators and Classic Eicosanoids in Biological Matrices.Journal of the American Society for Mass Spectrometry · 2024Article
- The enzymology of human eicosanoid pathways: the lipoxygenase branches.Molecular biology reports · 2020Review
- Leukotriene biosynthetic enzymes as therapeutic targets.The Journal of clinical investigation · 2018Review
- Leukotriene receptors as potential therapeutic targets.The Journal of clinical investigation · 2018Review
- Regulation of inflammation by lipid mediators in oral diseases.Oral diseases · 2017Review
- A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.The Journal of biological chemistry · 2014Article
- Structure and inhibition of mouse leukotriene C4 synthase.PloS one · 2014Article
- Humidity control and hydrophilic glue coating applied to mounted protein crystals improves X-ray diffraction experiments.Acta crystallographica. Section D, Biological crystallography · 2013Article
- A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid.Journal of biochemistry · 2013Article
- Sagittal focusing of synchrotron radiation X-rays using a winged crystal.Journal of synchrotron radiation · 2013Article
- Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-β-D-selenomaltoside.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.Chemical reviews · 2011Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Leukotriene (LT) C(4) and its metabolites, LTD(4) and LTE(4), are involved in the pathobiology of bronchial asthma. LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubility; that amphipathic LTA(4) as a derivative of arachidonic acid and a water-soluble glutathione (GSH). A previous crystal structure revealed important details of GSH binding and implied a GSH activating function for Arg-104. In addition, Arg-31 was also proposed to participate in the catalysis based on the putative LTA(4) binding model. In this study enzymatic assay with mutant enzymes demonstrates that Arg-104 is required for the binding and activation of GSH and that Arg-31 is needed for catalysis probably by activating the epoxide group of LTA(4).
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