ArticleRespiratory physiology & neurobiology2011
Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null mice.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits.Brain, behavior, and immunity · 2024Article
- Transgenic rodents as dynamic models for the study of respiratory rhythm generation and modulation: a scoping review and a bibliometric analysis.Frontiers in physiology · 2023Article
- Breathing patterns and CORespiratory physiology & neurobiology · 2023Article
- Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy.The Journal of physiology · 2017Article
- Serotonergic Control of Metabolic Homeostasis.Frontiers in cellular neuroscience · 2017Review
- Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knockout mice.Journal of neurophysiology · 2016Article
- Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.Cell metabolism · 2015Article
- RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO₂ insensitive brown Norway rat.The Journal of physiology · 2015Article
- The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception.Neuroscience · 2014Article
- Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Medullary serotonin neurons are CO2 sensitive in situ.Journal of neurophysiology · 2013Article
- Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice.Journal of neurochemistry · 2013Article
- Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ.Respiratory physiology & neurobiology · 2013Article
- Fluoxetine augments ventilatory CO2 sensitivity in Brown Norway but not Sprague Dawley rats.Respiratory physiology & neurobiology · 2013Article
- Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient mice.Experimental physiology · 2013Article
- Understanding the rhythm of breathing: so near, yet so far.Annual review of physiology · 2013Review
- The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The integrity of the serotonin (5-HT) system is essential to normal respiratory and thermoregulatory control. Male and female transgenic mice lacking central 5-HT neurons (Lmx1b(f/f/p) mice) show a 50% reduction in the hypercapnic ventilatory response and insufficient heat generation when cooled (Hodges and Richerson, 2008a; Hodges et al., 2008b). Lmx1b(f/f/p) mice also show reduced body temperatures (T(body)) and O(2) consumption [Formula: see text] , and breathe less at rest and during hypoxia and hypercapnia when measured below thermoneutrality (24 °C), suggesting a role for 5-HT neurons in integrating ventilatory, thermal and metabolic control. Here, the hypothesis that Pet-1 null mice, which retain 30% of central 5-HT neurons, will demonstrate similar deficits in temperature and ventilatory control was tested. Pet-1 null mice had fewer medullary tryptophan hydroxylase-immunoreactive (TPH(+)) neurons compared to wild type (WT) mice, particularly in the midline raphé. Female (but not male) Pet-1 null mice had lower baseline ventilation (V(E)), breathing frequency (f), [Formula: see text] and T(body) relative to female WT mice (P < 0.05). In addition, V(E) and [Formula: see text] were decreased in male and female Pet-1 null mice during hypoxia and hypercapnia (P < 0.05), but only male Pet-1 null mice showed a significant deficit in the hypercapnic ventilatory response when expressed as % of control (P < 0.05). Finally, male and female Pet-1 null mice showed significant decreases in T(body) when externally cooled to 4 °C. These data demonstrate that a moderate loss of 5-HT neurons leads to a modest attenuation of mechanisms defending body temperature, and that there are gender differences in the contributions of 5-HT neurons to ventilatory and thermoregulatory control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.