ArticleNeurobiology of learning and memory2011
Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.
Article in Neurobiology of learning and memory, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics.Journal of neurophysiology · 2019Article
- Consolidation of altered associability information by amygdala central nucleus.Neurobiology of learning and memory · 2016Article
- ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Intrahippocampal Anisomycin Impairs Spatial Performance on the Morris Water Maze.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Anisomycin infusions in the parabrachial nucleus and taste neophobia.Neurobiology of learning and memory · 2012Article
- Cycloheximide impairs and enhances memory depending on dose and footshock intensity.Behavioural brain research · 2012Article
- Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro.Acta pharmacologica Sinica · 2012Article
- Acquisition of "Start" and "Stop" response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum.Frontiers in integrative neuroscience · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When administered near the time of training, protein synthesis inhibitors such as anisomycin impair later memory. A common interpretation of these findings is that memory consolidation requires new protein synthesis initiated by training. However, recent findings support an alternative interpretation that abnormally large increases in neurotransmitter release after injections of anisomycin may be responsible for producing amnesia. In the present study, a local anesthetic was administered prior to anisomycin injections in an attempt to mitigate neurotransmitter actions and thereby attenuate the resulting amnesia. Rats received lidocaine and anisomycin injections into the amygdala 130 and 120 min, respectively, prior to inhibitory avoidance training. Memory tests 48 h later revealed that lidocaine attenuated anisomycin-induced amnesia. In other rats, in vivo microdialysis was performed at the site of amygdala infusion of lidocaine and anisomycin. As seen previously, anisomycin injections produced large increases in release of norepinephrine in the amygdala. Lidocaine attenuated the anisomycin-induced increase in release of norepinephrine but did not reverse anisomycin inhibition of protein synthesis, as assessed by c-Fos immunohistochemistry. These findings are consistent with past evidence suggesting that anisomycin causes amnesia by initiating abnormal release of neurotransmitters in response to the inhibition of protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.