ArticleNeuroscience2011
Differential effects of social defeat in rats with high and low locomotor response to novelty.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model.Biological psychiatry · 2021Pooled it
- Structural remodeling of medium spiny neurons in the tail of the striatum and stress-related behavioral alterations after early handling and adolescent stress in male rats.IBRO neuroscience reports · 2026Article
- Adolescent Stress Exposure: Behavioral Consequences and Molecular Mechanisms in Corticolimbic Networks.bioRxiv : the preprint server for biology · 2026Article
- Adolescent stress exposure: behavioral consequences and molecular mechanisms in corticolimbic networks.Frontiers in cellular neuroscience · 2026Article
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Locomotor Response to Novelty: What Does It Tell Us?Developmental psychobiology · 2025Article
- Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues.Brain sciences · 2022Review
- Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC).The European journal of neuroscience · 2022Review
- Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model.Translational psychiatry · 2022Article
- Epigenetic mechanisms underlying stress-induced depression.International review of neurobiology · 2021Article
- Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction.PPAR research · 2020Review
- Chronic non-discriminatory social defeat is an effective chronic stress paradigm for both male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats.Psychopharmacology · 2017Article
- Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats.Behavioural brain research · 2017Article
- Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.Neuropharmacology · 2016Article
- Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress.Neurobiology of stress · 2016Review
- HPA Axis Interactions with Behavioral Systems.Comprehensive Physiology · 2016Review
- Revealing a latent variable: individual differences in affective response to repeated injections.Behavioral neuroscience · 2015Article
- Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.Neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We compared the response to repeated social defeat in rats selected as high (HR) and low (LR) responders to novelty. In experiment 1, we investigated the behavioral and neuroendocrine effects of repeated social defeat in HR-LR rats. By the last defeat session, HR rats exhibited less passive-submissive behaviors than LR rats, and exhibited higher corticosterone secretion when recovering from defeat. Furthermore, in the forced swim test, while HR defeated rats spent more time immobile than their undefeated controls, LR rats' immobility was unaffected by defeat. In experiment 2, we compared the effects of repeated social defeat on body, adrenal, thymus, and spleen weights in HR-LR rats; moreover, we compared the effects of repeated social defeat on stress related molecules gene expression in these two groups of rats. Our results show that HR rats exhibited a decrease in thymus weight after repeated social defeat that was not present in LRs. Analyses of in situ hybridization results found HR-LR differences in 5-HT(2a) mRNA levels in the parietal cortex and 5-HT(1a) mRNA levels in the dorsal raphe. Moreover, LR rats had higher glucocorticoid receptor (GR) mRNA expression than HR rats in the dentate gyrus, and repeated social defeat decreased this expression in LR rats to HR levels. Finally, hippocampal mineralcorticoid receptor (MR)/GR ratio was reduced in HR rats only. Taken together, our results show a differential response to social defeat in HR-LR rats, and support the HR-LR model as a useful tool to investigate inter-individual differences in response to social stressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.