ArticleBMC pregnancy and childbirth2011
Quantitative effects of tobacco smoking exposure on the maternal-fetal circulation.
Article in BMC pregnancy and childbirth, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Tobacco Smoking During Pregnancy Is Associated With Increased Risk of Moderate/Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review.Journal of translational medicine · 2015Pooled it
- Prenatal Substance Exposure: Associations with Neurodevelopment in Middle Childhood.American journal of perinatology · 2024Article
- A prospective ultrasound study of cigarette smoking and uterine leiomyomata incidence and growth.American journal of obstetrics and gynecology · 2023Article
- Factors Affecting Menstrual Cycle Developmental Trajectory in Adolescents: A Narrative Review.International journal of endocrinology and metabolism · 2022Review
- Inadequate Gestational Weight Gain and Exposure to Second-Hand Smoke during Pregnancy Increase the Risk of Low Birth Weight: A Cross-Sectional Study among Full-Term Infants.International journal of environmental research and public health · 2021Article
- Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits.Translational research : the journal of laboratory and clinical medicine · 2019Article
- Prenatal air pollution exposure, smoking, and uterine vascular resistance.Environmental epidemiology (Philadelphia, Pa.) · 2018Article
- Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease.Frontiers in physiology · 2018Review
- Observational
- Nicotine Suppressed Fetal Adrenal StAR Expression via YY1 Mediated-Histone Deacetylation Modification Mechanism.International journal of molecular sciences · 2016Article
- Article
- Low level maternal smoking and infant birthweight reduction: genetic contributions of GSTT1 and GSTM1 polymorphisms.BMC pregnancy and childbirth · 2012Article
- Air pollution exposure and markers of placental growth and function: the generation R study.Environmental health perspectives · 2012Article
- Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production.Toxicology and applied pharmacology · 2011Article
- Effect of Maternal Cigarette Smoking on Newborn Iron Stores.Clinical research and trialsArticle
- Self-reported smoking status and urinary cotinine levels in patients with asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the existence of various published studies regarding the effects of tobacco smoking on pregnancy, and especially in regards to placental blood flow and vascular resistance, some points still require clarification. In addition, the amount of damage due to tobacco smoking exposure that occurs has not been quantified by objective means. In this study, we looked for a possible association between flow resistance indices of several arteries and the levels of urinary cotinine and the concentration of carbon monoxide in the exhaled air (COex) of both smoking and non-smoking pregnant women. We also looked for a relationship between those findings and fetal growth and birth weight.
methodsIn a prospective design, thirty pregnant smokers and thirty-four pregnant non-smokers were studied. The volunteers signed consent forms, completed a self-applied questionnaire and were subjected to Doppler velocimetry. Tobacco smoking exposure was quantified by subject provided information and confirmed by the measurement of urinary cotinine levels and by the concentration of carbon monoxide in the exhaled air (COex). The weight of newborns was evaluated immediately after birth.
resultsComparing smoking to non-smoking pregnant women, a significant increase in the resistance index was observed in the uterine arteries (P = 0.001) and umbilical artery (P = 0.001), and a decrease in the middle cerebral artery (P = 0.450). These findings were associated with progressively higher concentrations of COex and urinary cotinine. A decrease in the birth weight was also detected (P < 0.001) in association with a progressive increase in the tobacco exposure of the pregnant woman.
conclusionsIn pregnant women who smoke, higher arterial resistance indices and lower birth weights were observed, and these findings were associated with increasing levels of tobacco smoking exposure. The values were significantly different when compared to those found in non-smoking pregnant women. This study contributes to the findings that smoking damage during pregnancy is dose-dependent, as demonstrated by the objective methods for measuring tobacco smoking exposure.
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