ReviewThe European journal of neuroscience2011
In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system.
Review in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Animal Models of Autistic-like Behavior in Rodents: A Scoping Review and Call for a Comprehensive Scoring System.International journal of molecular sciences · 2024Article
- HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells.Viruses · 2022Article
- Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.Cellular and molecular life sciences : CMLS · 2020Article
- Rett Syndrome in Males: The Different Clinical Course in Two Brothers with the Same Microduplication MECP2 Xq28.International journal of environmental research and public health · 2019Article
- Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome.International journal of molecular sciences · 2019Review
- Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells.Stem cell research & therapy · 2019Article
- Article
- Alterations in the MicroRNA of the Blood of Autism Spectrum Disorder Patients: Effects on Epigenetic Regulation and Potential Biomarkers.Behavioral sciences (Basel, Switzerland) · 2018Article
- The Expression of Transcription Factors Mecp2 and CREB Is Modulated in Inflammatory Pelvic Pain.Frontiers in systems neuroscience · 2018Article
- Persistent Unresolved Inflammation in theMediators of inflammation · 2017Article
- Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.Investigative ophthalmology & visual science · 2015Article
- SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients.Neurobiology of disease · 2015Article
- Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome.Frontiers in behavioral neuroscience · 2015Article
- Circadian cycle-dependent MeCP2 and brain chromatin changes.PloS one · 2015Article
- Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- Folate and epigenetic mechanisms in neural tube development and defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Effects of ethanol exposure during early pregnancy in hyperactive, inattentive and impulsive behaviors and MeCP2 expression in rodent offspring.Neurochemical research · 2013Article
- A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.PloS one · 2013Article
- MicroRNAs: novel regulators of oligodendrocyte differentiation and potential therapeutic targets in demyelination-related diseases.Molecular neurobiology · 2012Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The array of specialized neuronal and glial cell types that characterize the adult central nervous system originates from neuroepithelial proliferating precursor cells. The transition from proliferating neuroepithelial precursor cells to neuronal lineages is accompanied by rapid global changes in gene expression in coordination with epigenetic modifications at the level of the chromatin structure. A number of genetic studies have begun to reveal how epigenetic deregulation results in neurodevelopmental disorders such as mental retardation, autism, Rubinstein-Taybi syndrome and Rett syndrome. In this review we focus on the role of the methyl-CpG binding protein 2 (MeCP2) during development of the central nervous system and its involvement in Rett syndrome. First, we present recent findings that indicate a previously unconsidered role of glial cells in the development of Rett syndrome. Next, we discuss evidence of how MeCP2 deficiency or loss of function results in aberrant gene expression leading to Rett syndrome. We also discuss MeCP2's function as a repressor and activator of gene expression and the role of its different target genes, including microRNAs, during neuronal development. Finally, we address different signaling pathways that regulate MeCP2 expression at both the post-transcriptional and post-translational level, and discuss how mutations in MeCP2 may result in lack of responsiveness to environmental signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.