Evidence map›Paper›PMID 21453214›Full record

ReviewExpert review of cardiovascular therapy2011

Radiation exposure from imaging tests: is there an increased cancer risk?

Patricia K Nguyen, Joseph C Wu

Abstract readReview
In one paragraph

Review in Expert review of cardiovascular therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  14. Review
  15. Article
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  18. Review
  19. Striking a balance in the discussion of the benefits of imaging tests and risks of radiation exposure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patricia K NguyenDepartment of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305-5111, USA. pnguyen@cvmed.stanford.edu
Joseph C Wu

Funding

Molecular Imaging of Targeted Cardiac Gene TherapyR01HL093172 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2009 to 2015
$2.7M
Molecular Imaging of Cardiac Stem Cell TherapyR01EB009689 · NIBIB · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2010 to 2013
$1.4M
The Impact and Value of Non-invasive Testing in the Management of Obstructive CADIK2HX000749 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI NGUYEN, PATRICIA KIM PHUONG · 2014 to 2015
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HSRD VA IK2 HX000749NHLBI NIH HHS HL093172NHLBI NIH HHS R01 HL093172NIBIB NIH HHS EB009689NIBIB NIH HHS R01 EB009689
6 · The paper itself

Abstract

The increasing exposure to low-dose radiation from diagnostic testing has prompted renewed interest in evaluating its carcinogenic risk, but quantifying health risk from low-dose radiation exposure remains controversial. The current approach is to adopt the linear non-threshold model, which is commonly applied to high-dose exposure, and apply it to assess risk from low-dose exposure. However, existing data are conflicting and limited to epidemiological studies and/or in vitro analyses. In this article, we will discuss the potential cancer risk from low- and high-dose radiation, their effects on DNA repair response pathways, and the best course of action for patients and providers to minimize risk.

Indexed as

AnimalsDNA DamageDNA RepairDose-Response Relationship, RadiationHumansNeoplasmsRadiation, IonizingRadiographyRadionuclide ImagingRisk AssessmentRisk Factors

Identifiers

PMID21453214
PMCPMC3102578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.