ArticleMagnetic resonance in medicine2011
T₁-corrected fat quantification using chemical shift-based water/fat separation: application to skeletal muscle.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Thigh muscle segmentation of chemical shift encoding-based water-fat magnetic resonance images: The reference database MyoSegmenTUM.PloS one · 2018Trial
- Heterogeneity of muscle fat infiltration in children with spina bifida.Research in developmental disabilities · 2014Trial
- Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients.Journal of magnetic resonance imaging : JMRI · 2013Trial
- Meal-Induced Proton Density Fat Fraction andNMR in biomedicine · 2026Article
- Phase-Sensitive Modeling Improves Fat DESPOT Multiparametric Relaxation Mapping in Fat-Water Mixtures.Magnetic resonance in medicine · 2026Article
- Article
- Longitudinal assessment of changes in muscle composition using proton density fat fraction and T2* in patients with and without incidental vertebral compression fractures.Frontiers in endocrinology · 2025Article
- Reproducibility of proton density fat fraction assessment of thigh muscle in a multi-site, multi-vendor cohort study at 10 years after anterior cruciate ligament reconstruction.Quantitative imaging in medicine and surgery · 2024Article
- Quantitative observation based on magnetic resonance imaging: the effects of marathon running on lumbar vertebrae, paraspinal muscles, and lumbar disc components.Quantitative imaging in medicine and surgery · 2024Article
- Association between myosteatosis and impaired glucose metabolism: A deep learning whole-body magnetic resonance imaging population phenotyping approach.Journal of cachexia, sarcopenia and muscle · 2024Article
- Use of two-point and six-point Dixon MRI for fat fraction analysis in the lumbar vertebral bodies and paraspinal muscles in healthy dogs: comparison with magnetic resonance spectroscopy.Frontiers in veterinary science · 2024Article
- Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study.European radiology · 2023Article
- Myosteatosis and bone marrow adiposity are not associated among postmenopausal women with fragility fractures.Frontiers in endocrinology · 2023Article
- Ultrasound and magnetic resonance imaging as diagnostic tools for sarcopenia in immune-mediated rheumatic diseases (IMRDs).La Radiologia medica · 2022Review
- Associations between Bone Mineral Density and Longitudinal Changes of Vertebral Bone Marrow and Paraspinal Muscle Composition Assessed Using MR-Based Proton Density Fat Fraction and T2* Maps in Patients with and without Osteoporosis.Diagnostics (Basel, Switzerland) · 2022Article
- Differentiation of bone metastases from benign red marrow depositions of the spine: the role of fat-suppressed T2-weighted imaging compared to fat fraction map.European radiology · 2022Article
- Associations of Texture Features of Proton Density Fat Fraction Maps between Lumbar Vertebral Bone Marrow and Paraspinal Musculature.Biomedicines · 2022Article
- MR-based proton density fat fraction (PDFF) of the vertebral bone marrow differentiates between patients with and without osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Associations of incidental vertebral fractures and longitudinal changes of MR-based proton density fat fraction and T2* measurements of vertebral bone marrow.Frontiers in endocrinology · 2022Article
- Stimulatory Effect of Tofacitinib on Bone Marrow Adipocytes Differentiation.Frontiers in endocrinology · 2022Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chemical shift-based water/fat separation, like iterative decomposition of water and fat with echo asymmetry and least-squares estimation, has been proposed for quantifying intermuscular adipose tissue. An important confounding factor in iterative decomposition of water and fat with echo asymmetry and least-squares estimation-based intermuscular adipose tissue quantification is the large difference in T(1) between muscle and fat, which can cause significant overestimation in the fat fraction. This T(1) bias effect is usually reduced by using small flip angles. T(1) -correction can be performed by using at least two different flip angles and fitting for T(1) of water and fat. In this work, a novel approach for the water/fat separation problem in a dual flip angle experiment is introduced and a new approach for the selection of the two flip angles, labeled as the unequal small flip angle approach, is developed, aiming to improve the noise efficiency of the T(1) -correction step relative to existing approaches. It is shown that the use of flip angles, selected such the muscle water signal is assumed to be T(1) -independent for the first flip angle and the fat signal is assumed to be T(1) -independent for the second flip angle, has superior noise performance to the use of equal small flip angles (no T(1) estimation required) and the use of large flip angles (T(1) estimation required).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.