ArticleThe Journal of comparative neurology2011
Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026Review
- BrainConnect: processing brain connectivity and spatial transcriptomics data for integrative analysis.Bioinformatics (Oxford, England) · 2026Article
- Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits.BMC genomics · 2025Article
- The Transcription FactorCancers · 2021Article
- Article
- Mechanisms underlying pre- and postnatal development of the vomeronasal organ.Cellular and molecular life sciences : CMLS · 2021Review
- Neurobiology of zinc and its role in neurogenesis.European journal of nutrition · 2021Review
- Article
- Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1.Frontiers in cell and developmental biology · 2020Article
- Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway.Journal of molecular neuroscience : MN · 2018Article
- Analysis of Downs syndrome with molecular techniques for future diagnoses.Saudi journal of biological sciences · 2018Review
- Update on the Genetics of Idiopathic Hypogonadotropic Hypogonadism.Journal of clinical research in pediatric endocrinology · 2017Review
- Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway.Molecular cancer · 2017Article
- Insights from exome sequencing for endocrine disorders.Nature reviews. Endocrinology · 2015Review
- Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia.Neuron · 2015Article
- Mutations in FEZF1 cause Kallmann syndrome.American journal of human genetics · 2014Article
- Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.Neural development · 2014Article
- Splicing factor TRA2B is required for neural progenitor survival.The Journal of comparative neurology · 2014Article
- Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons.The Journal of comparative neurology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The murine olfactory system consists of main and accessory systems that perform distinct and overlapping functions. The main olfactory epithelium (MOE) is primarily involved in the detection of volatile odorants, while neurons in the vomeronasal organ (VNO), part of the accessory olfactory system, are important for pheromone detection. During development, the MOE and VNO both originate from the olfactory pit; however, the mechanisms regulating development of these anatomically distinct organs from a common olfactory primordium are unknown. Here we report that two closely related zinc-finger transcription factors, FEZF1 and FEZF2, regulate the identity of MOE sensory neurons and are essential for the survival of VNO neurons respectively. Fezf1 is predominantly expressed in the MOE while Fezf2 expression is restricted to the VNO. In Fezf1-deficient mice, olfactory neurons fail to mature and also express markers of functional VNO neurons. In Fezf2-deficient mice, VNO neurons degenerate prior to birth. These results identify Fezf1 and Fezf2 as important regulators of olfactory system development and sensory neuron identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.