ArticleThe Journal of comparative neurology2011
Formation of the spinal network in zebrafish determined by domain-specific pax genes.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish.Communications biology · 2025Article
- Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.Biology open · 2023Article
- Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023Review
- Zebrafish Embryos and Larvae as Alternative Animal Models for Toxicity Testing.International journal of molecular sciences · 2021Review
- Pou3f4-expressing otic mesenchyme cells promote spiral ganglion neuron survival in the postnatal mouse cochlea.The Journal of comparative neurology · 2020Article
- Article
- sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish.Developmental biology · 2018Article
- Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue.Scientific reports · 2017Article
- Cone signals in monostratified and bistratified amacrine cells of adult zebrafish retina.The Journal of comparative neurology · 2017Article
- A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Maternal thyroid hormones are essential for neural development in zebrafish.Molecular endocrinology (Baltimore, Md.) · 2014Article
- HNF1β is essential for nephron segmentation during nephrogenesis.Journal of the American Society of Nephrology : JASN · 2013Article
- The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study.Biochemical pharmacology · 2012Article
- Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Conditions that influence the response to Fgf during otic placode induction.Developmental biology · 2012Article
- Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development.Development, growth & differentiation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
In the formation of the spinal network, various transcription factors interact to develop specific cell types. By using a gene trap technique, we established a stable line of zebrafish in which the red fluorescent protein (RFP) was inserted into the pax8 gene. RFP insertion marked putative pax8-lineage cells with fluorescence and inhibited pax8 expression in homozygous embryos. Pax8 homozygous embryos displayed defects in the otic vesicle, as previously reported in studies with morpholinos. The pax8 homozygous embryos survived to adulthood, in contrast to mammalian counterparts that die prematurely. RFP is expressed in the dorsal spinal cord. Examination of the axon morphology revealed that RFP(+) neurons include commissural bifurcating longitudinal (CoBL) interneurons, but other inhibitory neurons such as commissural local (CoLo) interneurons and circumferential ascending (CiA) interneurons do not express RFP. We examined the effect of inhibiting pax2a/pax8 expression on interneuron development. In pax8 homozygous fish, the RFP(+) cells underwent differentiation similar to that of pax8 heterozygous fish, and the swimming behavior remained intact. In contrast, the RFP(+) cells of pax2a/pax8 double mutants displayed altered cell fates. CoBLs were not observed. Instead, RFP(+) cells exhibited axons descending ipsilaterally, a morphology resembling that of V2a/V2b interneurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.