ArticleThe Journal of comparative neurology2011
Neurogliaform cells in the molecular layer of the dentate gyrus as feed-forward γ-aminobutyric acidergic modulators of entorhinal-hippocampal interplay.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Sparsification and decorrelation of granule cell activity in the dentate gyrus by noradrenaline.Communications biology · 2026Article
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- Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy.International journal of molecular sciences · 2024Article
- Interneuron diversity in the rat dentate gyrus: An unbiased in vitro classification.Hippocampus · 2022Article
- Article
- Neurogliaform cells mediate feedback inhibition in the medial entorhinal cortex.Frontiers in neuroanatomy · 2022Article
- Hypothalamic Glutamate/GABA Cotransmission Modulates Hippocampal Circuits and Supports Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Epistemic Autonomy: Self-supervised Learning in the Mammalian Hippocampus.Trends in cognitive sciences · 2021Review
- Dorsal and ventral mossy cells differ in their axonal projections throughout the dentate gyrus of the mouse hippocampus.Hippocampus · 2021Article
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.eLife · 2020Article
- Operations Research Methods for Estimating the Population Size of Neuron Types.Annals of operations research · 2020Article
- Molecular expression profiles of morphologically defined hippocampal neuron types: Empirical evidence and relational inferences.Hippocampus · 2020Article
- Quantitative firing pattern phenotyping of hippocampal neuron types.Scientific reports · 2019Article
- Interplay of Entorhinal Input and Local Inhibitory Network in the Hippocampus at the Origin of Slow Inhibition in Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neuron Names: A Gene- and Property-Based Name Format, With Special Reference to Cortical Neurons.Frontiers in neuroanatomy · 2019Article
- Progesterone receptor expression in cajal-retzius cells of the developing rat dentate gyrus: Potential role in hippocampus-dependent memory.The Journal of comparative neurology · 2018Article
- Morphological diversity and connectivity of hippocampal interneurons.Cell and tissue research · 2018Review
- Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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4 authors.
Funding
Abstract
Feed-forward inhibition from molecular layer interneurons onto granule cells (GCs) in the dentate gyrus is thought to have major effects regulating entorhinal-hippocampal interactions, but the precise identity, properties, and functional connectivity of the GABAergic cells in the molecular layer are not well understood. We used single and paired intracellular patch clamp recordings from post-hoc-identified cells in acute rat hippocampal slices and identified a subpopulation of molecular layer interneurons that expressed immunocytochemical markers present in members of the neurogliaform cell (NGFC) class. Single NGFCs displayed small dendritic trees, and their characteristically dense axonal arborizations covered significant portions of the outer and middle one-thirds of the molecular layer, with frequent axonal projections across the fissure into the CA1 and subicular regions. Typical NGFCs exhibited a late firing pattern with a ramp in membrane potential prior to firing action potentials, and single spikes in NGFCs evoked biphasic, prolonged GABA(A) and GABA(B) postsynaptic responses in GCs. In addition to providing dendritic GABAergic inputs to GCs, NGFCs also formed chemical synapses and gap junctions with various molecular layer interneurons, including other NGFCs. NGFCs received low-frequency spontaneous synaptic events, and stimulation of perforant path fibers revealed direct, facilitating synaptic inputs from the entorhinal cortex. Taken together, these results indicate that NGFCs form an integral part of the local molecular layer microcircuitry generating feed-forward inhibition and provide a direct GABAergic pathway linking the dentate gyrus to the CA1 and subicular regions through the hippocampal fissure.
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