ArticleCellular and molecular life sciences : CMLS2011
Retron Se72 utilizes a unique strategy of the self-priming initiation of reverse transcription.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genetic Characterization of a Novel Retron Element Isolated from Vibrio mimicus.Microbiology and immunology · 2025Article
- Retrons and their applications in genome engineering.Nucleic acids research · 2019Review
- Chicken innate immune response to oral infection with Salmonella enterica serovar Enteritidis.Veterinary research · 2013Article
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Authors and funding
2 authors.
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Abstract
Unlike all of the other retrons, the bacterial retron reverse transcriptase RrtE is capable of synthesizing small double-stranded DNA (sdsDNA) from template RNA. In this study, we analyzed the biosynthesis of the sdsDNA by RrtE in detail. We found out that the initiation of reverse transcription was dependent on a novel self-priming mechanism utilizing a free 3'OH of RNA that is reverse-transcribed into sdsDNA. The priming of the sdsDNA synthesis was not dependent on any particular nucleotide being used as a donor of 3'OH (unlike all of the other retrons, which prime from 2'OH of a particular guanosine) or any particular nucleotide being introduced into the sdsDNA first. Due to the relaxed demands for the initiation of reverse transcription, RrtE has the potential to generate dsDNA from different RNA transcripts in vivo.
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