ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Preoptic-raphé connections for thermoregulatory vasomotor control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats.Current biology : CB · 2025Article
- Neural cell-types and circuits linking thermoregulation and social behavior.Neuroscience and biobehavioral reviews · 2024Review
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
- Central Mechanisms of Thermoregulation and Fever in Mammals.Advances in experimental medicine and biology · 2024Review
- Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.Science advances · 2022Article
- The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years?International journal of molecular sciences · 2022Review
- A hypothalamomedullary network for physiological responses to environmental stresses.Nature reviews. Neuroscience · 2022Review
- The Effects of Estrogens on Neural Circuits That Control Temperature.Endocrinology · 2021Review
- Physiological and Behavioral Mechanisms of Thermoregulation in Mammals.Animals : an open access journal from MDPI · 2021Review
- Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice.Nature communications · 2020Article
- Parabrachial neuron types categorically encode thermoregulation variables during heat defense.Science advances · 2020Article
- EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neurons in the rat ventral lateral preoptic area are essential for the warm-evoked inhibition of brown adipose tissue and shivering thermogenesis.Acta physiologica (Oxford, England) · 2019Article
- Central nervous system circuits that control body temperature.Neuroscience letters · 2019Review
- Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia.PLoS biology · 2019Article
- Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice.Nature communications · 2018Article
- A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia.Current biology : CB · 2018Article
- Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Review
- The Hypothalamic Preoptic Area and Body Weight Control.Neuroendocrinology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood flow to glabrous skin such as the rat's tail determines heat dissipation from the body and is regulated by sympathetic vasoconstrictor nerves. Tail vasoconstrictor activity is tonically inhibited by neurons in two distinct preoptic regions, rostromedial (RMPO) and caudolateral (CLPO) regions, whose actions may be via direct projections to medullary raphé premotor neurons. In urethane-anesthetized rats, we sought single preoptic neurons that were antidromically activated from the medullary raphé and could subserve this function. Nine of 45 raphé-projecting preoptic neurons, predominantly in the CLPO, showed spontaneous activity under warm conditions and were inhibited by cooling the trunk skin (warm-responsive). Unexpectedly, 14 raphé-projecting preoptic neurons (mostly in the RMPO) were activated by skin cooling (cold-responsive), suggesting that an excitatory pathway from this region could contribute to tail vasoconstriction. Supporting this, neuronal disinhibition in the RMPO by microinjecting the GABA(A) receptor antagonist bicuculline (0.5 mm, 15 nl) caused a rapid increase in tail sympathetic nerve activity (SNA). Similar injections into the CLPO were without effect. Electrical stimulation of the RMPO also activated tail SNA, with a latency ∼25 ms longer than to stimulation of the medullary raphé. Injection of the glutamate receptor antagonist kynurenate (50 mm, 120 nl) into the medullary raphé suppressed tail SNA responses to both RMPO bicuculline and skin cooling. These findings suggest that both inhibitory and excitatory descending drives regulate tail vasoconstriction in the cold and that warm- and cold-responsive raphé-projecting preoptic neurons may mediate these actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.