ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Inputs underlying the ON-OFF light responses of type 2 wide-field amacrine cells in TH::GFP mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina.Nature neuroscience · 2025Article
- Article
- Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse.Investigative ophthalmology & visual science · 2022Article
- Lhx9 Is Required for the Development of Retinal Nitric Oxide-Synthesizing Amacrine Cell Subtype.Molecular neurobiology · 2018Article
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.Frontiers in molecular neuroscience · 2018Article
- Inhibitory Control of Feature Selectivity in an Object Motion Sensitive Circuit of the Retina.Cell reports · 2017Article
- Differential Distribution of Retinal CaFrontiers in molecular neuroscience · 2017Article
- A tale of two neurotransmitters.Visual neuroscience · 2016Review
- Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.Neuroscience · 2015Article
- Function and Circuitry of VIP+ Interneurons in the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Commentary: "Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity".Frontiers in cellular neuroscience · 2015Article
- Synaptic connections of amacrine cells containing vesicular glutamate transporter 3 in baboon retinas.Visual neuroscience · 2015Article
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
- Electrical stimulation of inner retinal neurons in wild-type and retinally degenerate (rd/rd) mice.PloS one · 2013Article
- Receptor targets of amacrine cells.Visual neuroscience · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mammalian retina, two types of catecholaminergic amacrine cells have been described. Although dopaminergic type 1 cells are well characterized, the physiology of type 2 cells is, so far, unknown. To target type 2 cells specifically, we used a transgenic mouse line that expresses green fluorescent protein under the control of the tyrosine hydroxylase promoter. Type 2 cells are GABAergic and have an extensive dendritic arbor, which stratifies in the middle of the inner plexiform layer. Our data suggest that type 2 cells comprise two subpopulations with identical physiological properties: one has its somata located in the inner nuclear layer and the other in the ganglion cell layer. Immunostaining with bipolar cell markers suggested that type 2 cells receive excitatory inputs from type 3 OFF and type 5 ON bipolar cells. Consistently, patch-clamp recordings showed that type 2 cells are ON-OFF amacrine cells. Blocking excitatory inputs revealed that different rod and cone pathways are active under scotopic and mesopic light conditions. Blockade of inhibitory inputs led to membrane potential oscillations in type 2 cells, suggesting that GABAergic and glycinergic amacrine cells strongly influence type 2 cell signaling. Among the glycinergic amacrine cells, we identified the VGluT3-immunoreactive amacrine cell as a likely candidate. Collectively, light responses of type 2 cells were remarkably uniform over a wide range of light intensities. These properties point toward a general function of type 2 cells that is maintained under scotopic and mesopic conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.