Evidence map›Paper›PMID 21450917›Full record

ReviewInvestigative ophthalmology & visual science2011

The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD.

Debra A Schaumberg, Jason J Nichols, Eric B Papas, Louis Tong, Miki Uchino, Kelly K Nichols

6 registry-linked trialsAbstract readReview
In one paragraph

Review in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 249 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01600625 nacompletednot on this map

Effects of Minocycline on Cytokine Levels in Severe Meibomian Gland Dysfunction

TypeinterventionalSponsorYonsei UniversityRan2011 to 2013Enrolled46ConditionsMeibomian Gland DysfunctionArmsoral minocycline hydrochloride treatment
NCT03767530 narecruitingnot on this mapstarted 2019, after this paper: background citation

Efficacy and Safety of Thermic Devices in the Treatment of Meibomian Gland Dysfunction

TypeinterventionalSponsorUniversidad Autonoma de Nuevo LeonRan2019 to 2027Enrolled42ConditionsMeibomian Gland DysfunctionArmsMibo Thermoflo, Warm compresses and eyelid massage
NCT03953118 phase4terminatednot on this mapstarted 2019, after this paper: background citation

A Randomized, Controlled Trial to Evaluate the Role of Oral Azithromycin in the Treatment of Symptomatic Meibomian Gland Disease and Its Effect on the Ocular Surface Microbiome

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2021Enrolled2ConditionsDry Eye, Neuropathic Eye Pain, Ocular Microbiome, Depression, AnxietyArmsAzithromycin Oral Product, Placebo Oral
NCT05577910 nacompletednot on this mapstarted 2022, after this paper: background citation

Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress (VIEW) Therapies for Meibomian Gland Dysfunction- A Randomized, Assessor-masked, Active-controlled Clinical Trial

TypeinterventionalSponsorChinese University of Hong KongRan2022 to 2025Enrolled374ConditionsMeibomian Gland DysfunctionArmsVectored thermal pulsation (VTP) therapy, Intense pulsed light with meibomian gland expression (IPL+MGX) therapy, Eyelid Warm Compress Therapy (EW), Topical eye drops (Hypromellose, 3mg/ml)
NCT06220474 narecruitingnot on this mapstarted 2024, after this paper: background citation

Therapeutic Efficacy and Safety of Non-Invasive Radiofrequency Treatment in Patients With Refractory Meibomian Gland Dysfunction: A Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2024 to 2027Enrolled112ConditionsDry Eye Syndromes, Meibomian Gland DysfunctionArmsThe Thermage FLX System, Sham treatment
NCT06392438 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Combination of 0.09% Cyclosporine and Intense Pulsed Light (IPL) Therapy for the Treatment of Dry Eye Disease in Symptomatic Contact Lens Wearers: a Sham-Controlled Randomized Clinical Trial

TypeinterventionalSponsorUniversité de SherbrookeRan2024 to 2025Enrolled44ConditionsDry Eye, Contact Lens ComplicationArmsCycloSPORINE Ophthalmic, Intense Pulsed Light, Sham Intense Pulse Light
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Efficacy of eyelid warming therapies in contact lens-related dry eye and comfortable wearing time: a systematic review with meta-analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Pooled it
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  17. Efficacy of azithromycin 1.5% eyedrops vs oral doxycycline in meibomian gland dysfunction: a randomized trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Trial
  18. Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease Due to Meibomian Gland Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2017
    Trial
  19. Trial
  20. Review

189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Debra A SchaumbergDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jason J Nichols
Eric B Papas
Louis Tong
Miki Uchino
Kelly K Nichols

Funding

Dry Eye in PostmenopauseR01EY015519 · NEI · UNIVERSITY OF HOUSTON · PI NICHOLS, KELLY K · 2007 to 2011
$1.7M
Interferometric Studies of the Fluid Dynamics of the Tear FilmR01EY017951 · NEI · OHIO STATE UNIVERSITY · PI KING-SMITH, PETER E · 2009 to 2012
$1.2M
Clinical Trial of Essential Fatty Acids for Dry Eye Disease: Planning GrantR34EY017626 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ASBELL, PENNY · 2008 to 2009
$477k
NEI NIH HHS 5R34 EY017626NEI NIH HHS R01 EY015519NEI NIH HHS R01 EY017951
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Meibomian GlandsEyelid DiseasesGlobal HealthHumansPrevalenceRisk Factors

Identifiers

PMID21450917
PMCPMC3072161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.