Evidence map›Paper›PMID 21450915›Full record

ReviewInvestigative ophthalmology & visual science2011

The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland.

Erich Knop, Nadja Knop, Thomas Millar, Hiroto Obata, David A Sullivan

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 473 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
473citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01600625 nacompletednot on this map

Effects of Minocycline on Cytokine Levels in Severe Meibomian Gland Dysfunction

TypeinterventionalSponsorYonsei UniversityRan2011 to 2013Enrolled46ConditionsMeibomian Gland DysfunctionArmsoral minocycline hydrochloride treatment
NCT02645045 completednot on this mapstarted 2015, after this paper: background citation

Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness

TypeobservationalSponsorYonsei UniversityRan2015 to 2016Enrolled350ConditionsDry Eye Syndrome
NCT03953118 phase4terminatednot on this mapstarted 2019, after this paper: background citation

A Randomized, Controlled Trial to Evaluate the Role of Oral Azithromycin in the Treatment of Symptomatic Meibomian Gland Disease and Its Effect on the Ocular Surface Microbiome

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2021Enrolled2ConditionsDry Eye, Neuropathic Eye Pain, Ocular Microbiome, Depression, AnxietyArmsAzithromycin Oral Product, Placebo Oral
NCT04052841 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Automated Morphological Analysis of Meibomian Glands

TypeinterventionalSponsorZhongshan Ophthalmic Center, Sun Yat-sen UniversityRan2020 to 2023Enrolled180ConditionsMeibomian Gland DysfunctionArmsThermal pulsation, Intense pulsed light therapy, Manual warm compresses
3 · Its place in the literature

Who cites it

473 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. LipiFlow for the treatment of dry eye disease: A Cochrane systematic review summary.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025
    Pooled it
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  4. LipiFlow for the treatment of dry eye disease.The Cochrane database of systematic reviews · 2024
    Pooled it
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  10. Effects of HP-Guar Nano-emulsion Artificial Tears on Symptoms and Severity of Meibomian Gland Dysfunction in Evaporative Dry Eye During a 90-Day Longitudinal Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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413 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erich KnopOcular Surface Center Berlin, Department for Cell and Neurobiology, Center for Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Nadja Knop
Thomas Millar
Hiroto Obata
David A Sullivan

Funding

Sex, sex steroids and dry eye syndromesR01EY005612 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI SULLIVAN, DAVID A. · 1985 to 2014
$9.0M
NEI NIH HHS R01 EY005612NEI NIH HHS R01 EY05612
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Meibomian GlandsHumans

Identifiers

PMID21450915
PMCPMC3072159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.