ArticleProceedings. Biological sciences2011
Genomic sweep and potential genetic rescue during limiting environmental conditions in an isolated wolf population.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Assessing the Genetic Health and Conservation Value of an Introduced Urban Population of a Critically Endangered Parrot.Evolutionary applications · 2026Article
- A Dominant Founder Lineage Has Possible Fitness Costs for the Endangered Mexican Grey Wolf.Molecular ecology · 2026Article
- Genetic rescue of Florida panthers reduced homozygosity but did not swamp ancestral genotypes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic Analysis Reveals Inbreeding in an Island Population of Alexander Archipelago Wolves.Evolutionary applications · 2025Article
- Genetic Connectivity in a Cooperatively Breeding Carnivore Between Two Protected Areas.Ecology and evolution · 2025Article
- Development of a Noninvasive Genotyping-In-Thousands (GTseq) Panel for Long-Term Conservation of Western Great Lakes Gray Wolves (Ecology and evolution · 2025Article
- Translocations spur population growth but fail to prevent genetic erosion in imperiled Florida Scrub-Jays.Current biology : CB · 2025Article
- Genomic Insights Into Inbreeding and Adaptive Divergence of Trout Populations to Inform Genetic Rescue.Evolutionary applications · 2025Article
- The evolutionary dynamics of local adaptations under genetic rescue is determined by mutational load and polygenicity.The Journal of heredity · 2024Article
- Tests of evolutionary and genetic rescue using flour beetles,Ecology and evolution · 2024Article
- Structural genomic variation in the inbred Scandinavian wolf population contributes to the realized genetic load but is positively affected by immigration.Evolutionary applications · 2024Article
- The far-reaching effects of genetic process in a keystone predator species, grey wolves.Science advances · 2023Article
- Genomic Underpinnings of Population Persistence in Isle Royale Moose.Molecular biology and evolution · 2023Article
- Methodological challenges in the genomic analysis of an endangered mammal population with low genetic diversity.Scientific reports · 2022Article
- Genomic evidence for inbreeding depression and purging of deleterious genetic variation in Indian tigers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Low Persistence of Genetic Rescue Across Generations in the Arctic Fox (Vulpes lagopus).The Journal of heredity · 2021Article
- Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression.Evolution letters · 2021Article
- Evaluating wildlife translocations using genomics: A bighorn sheep case study.Ecology and evolution · 2020Article
- Recent evolutionary history predicts population but not ecosystem-level patterns.Ecology and evolution · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Genetic rescue, in which the introduction of one or more unrelated individuals into an inbred population results in the reduction of detrimental genetic effects and an increase in one or more vital rates, is a potentially important management tool for mitigating adverse effects of inbreeding. We used molecular techniques to document the consequences of a male wolf (Canis lupus) that immigrated, on its own, across Lake Superior ice to the small, inbred wolf population in Isle Royale National Park. The immigrant's fitness so exceeded that of native wolves that within 2.5 generations, he was related to every individual in the population and his ancestry constituted 56 per cent of the population, resulting in a selective sweep of the total genome. In other words, all the male ancestry (50% of the total ancestry) descended from this immigrant, plus 6 per cent owing to the success of some of his inbred offspring. The immigration event occurred in an environment where space was limiting (i.e. packs occupied all available territories) and during a time when environmental conditions had deteriorated (i.e. wolves' prey declined). These conditions probably explain why the immigration event did not obviously improve the population's demography (e.g. increased population numbers or growth rate). Our results show that the beneficial effects of gene flow may be substantial and quickly manifest, short-lived under some circumstances, and how the demographic benefits of genetic rescue might be masked by environmental conditions.
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