ArticleJournal of psychiatric research2011
Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample.
Article in Journal of psychiatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical characteristics of obsessive-compulsive disorder comorbid with obsessive -compulsive personality disorder: subtype implications.Frontiers in psychiatry · 2025Article
- Hikikomori: A Scientometric Review of 20 Years of Research.International journal of environmental research and public health · 2023Review
- Pathological social withdrawal in autism spectrum disorder: A case control study of hikikomori in Japan.Frontiers in psychiatry · 2023Article
- The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.Journal of cellular and molecular medicine · 2021Article
- The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study.Comprehensive psychiatry · 2020Article
- Polymorphism of serotonin transporter gene in male subjects with antisocial behavior and MMA fighters.Translational psychiatry · 2018Article
- Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.Scientific reports · 2018Article
- Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders.Gastroenterology research and practice · 2017Article
- Genetic and Neuroimaging Features of Personality Disorders: State of the Art.Neuroscience bulletin · 2016Review
- Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Review
- Obsessive-compulsive personality disorder: a current review.Current psychiatry reports · 2015Review
- High social support buffers the effects of 5-HTTLPR genotypes within social anxiety disorder.European archives of psychiatry and clinical neuroscience · 2014Article
- Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.Emotion (Washington, D.C.) · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe serotonin transporter (SERT) polymorphism (5HTTLPR) has been reported to be associated with several psychiatric conditions. Specific personality disorders could be intermediate factors in the known relationship between 5HTTLPR and psychiatric disorders. This is the first study to test the association between this polymorphism and dimensions of all DSM-IV personality disorders in a community sample.
methods374 white participants were assessed by clinical psychologists using the International Personality Disorder Examination (IPDE). Associations between dimensions of each DSM-IV personality disorder and the long (l) and short (s) alleles of the 5HTTLPR were evaluated using non-parametric tests and regression models.
resultsThe s allele of the 5HTTLPR polymorphism was significantly associated with higher avoidant personality trait scores in the whole sample. Males with the s allele had a significantly lower likelihood of higher obsessive-compulsive personality disorder (OCPD) trait scores, whereas females with the s allele were likely to have higher OCPD personality trait scores.
conclusionThis paper provides preliminary data on the relationship between personality disorders and the 5HTTLPR polymorphism. The relationship of the s allele and avoidant PD is consistent with findings of a nonspecific relationship of this polymorphism to anxiety and depressive disorders. Concerning the unusual sexual dimorphic result with OCPD, several hypotheses are presented. These findings need further replication, including a more detailed study of additional variants in SERT.
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