ArticleMolecular pain2011
Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization.
Article in Molecular pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Investigating the Role of Artemin and Its Cognate Receptor, GFRα3, in Osteoarthritis Pain.Frontiers in neuroscience · 2022Article
- RET-independent signaling by GDNF ligands and GFRα receptors.Cell and tissue research · 2020Review
- Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson's disease.Cell and tissue research · 2020Review
- Drug-Induced HSP90 Inhibition Alleviates Pain in Monoarthritic Rats and Alters the Expression of New Putative Pain Players at the DRG.Molecular neurobiology · 2018Article
- Article
- Molecular Mechanisms That Contribute to Bone Marrow Pain.Frontiers in neurology · 2017Review
- Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- CaMKK-CaMK1a, a new post-traumatic signalling pathway induced in mouse somatosensory neurons.PloS one · 2014Article
- Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Prognostic significance of the expression of GFRα1, GFRα3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma.BMC cancer · 2013Article
- RET PLCγ phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration.PloS one · 2012Article
- The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a.Experimental neurology · 2012Article
- Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury.PloS one · 2011Article
- Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.Molecular painArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe GDNF family ligands (GFLs) are regulators of neurogenic inflammation and pain. We have previously shown that GFLs increase the release of the sensory neuron neuropeptide, calcitonin gene-related peptide (CGRP) from isolated mouse DRG.
resultsInhibitors of the mitogen-activated protein kinase (MAPK) pathway abolished the enhancement of CGRP release by GDNF. Neurturin-induced enhancement in the stimulated release of CGRP, used as an indication of sensory neuronal sensitization, was abolished by inhibition of the phosphatidylinositol-3 kinase (PI-3K) pathway. Reduction in Ret expression abolished the GDNF-induced sensitization, but did not fully inhibit the increase in stimulus-evoked release of CGRP caused by neurturin or artemin, indicating the presence of Ret-independent GFL-induced signaling in sensory neurons. Integrin β-1 and NCAM are involved in a component of Ret-independent GFL signaling in sensory neurons.
conclusionsThese data demonstrate the distinct and variable Ret-dependent and Ret-independent signaling mechanisms by which GFLs induce sensitization of sensory neurons. Additionally, there is a clear disconnect between intracellular signaling pathway activation and changes in sensory neuronal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.