ArticleBMC bioinformatics2011
An agent-based model to study the epidemiological and evolutionary dynamics of Influenza viruses.
Article in BMC bioinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives.NPJ systems biology and applications · 2026Review
- A time-delayed epidemic model for control of highly pathogenic avian influenza (HPAI H5Nx) with vaccination, compliance, and non-pharmaceutical interventions.Frontiers in public health · 2026Article
- An Intelligent ABM-based Framework for Developing Pandemic-Resilient Urban Spaces in Post-COVID Smart Cities.Procedia computer science · 2023Article
- Ecological and evolutionary dynamics of multi-strain RNA viruses.Nature ecology & evolution · 2022Review
- Endogenous viral mutations, evolutionary selection, and containment policy design.Journal of economic interaction and coordination · 2022Article
- Article
- Inference in epidemiological agent-based models using ensemble-based data assimilation.PloS one · 2022Article
- Forecasting emergence of COVID-19 variants of concern.PloS one · 2022Article
- An Agent-Based Model of the Local Spread of SARS-CoV-2: Modeling Study.JMIR medical informatics · 2021Article
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- Article
- Impact of age-specific immunity on the timing and burden of the next Zika virus outbreak.PLoS neglected tropical diseases · 2019Article
- The Kendrick modelling platform: language abstractions and tools for epidemiology.BMC bioinformatics · 2019Article
- Transmissible cancer and the evolution of sex.PLoS biology · 2019Article
- Human mobility networks and persistence of rapidly mutating pathogens.Royal Society open science · 2017Article
- Modeling Heterogeneity in Direct Infectious Disease Transmission in a Compartmental Model.International journal of environmental research and public health · 2016Article
- Optimizing agent-based transmission models for infectious diseases.BMC bioinformatics · 2015Article
- Mathematical and computational approaches to epidemic modeling: a comprehensive review.Frontiers of computer science · 2015Review
- Adaptive evolution and environmental durability jointly structure phylodynamic patterns in avian influenza viruses.PLoS biology · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundInfluenza A viruses exhibit complex epidemiological patterns in a number of mammalian and avian hosts. Understanding transmission of these viruses necessitates taking into account their evolution, which represents a challenge for developing mathematical models. This is because the phrasing of multi-strain systems in terms of traditional compartmental ODE models either requires simplifying assumptions to be made that overlook important evolutionary processes, or leads to complex dynamical systems that are too cumbersome to analyse.
resultsHere, we develop an Individual-Based Model (IBM) in order to address simultaneously the ecology, epidemiology and evolution of strain-polymorphic pathogens, using Influenza A viruses as an illustrative example.
conclusionsWe carry out careful validation of our IBM against comparable mathematical models to demonstrate the robustness of our algorithm and the sound basis for this novel framework. We discuss how this new approach can give critical insights in the study of influenza evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.