ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011
IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- Innate Immune Memory Responses in Organ Transplantation.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Article
- Mechanisms governing bystander activation of T cells.Frontiers in immunology · 2024Review
- Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.The Journal of clinical investigation · 2023Article
- Gut Microbiome in Patients after Heart Transplantation-Current State of Knowledge.Biomedicines · 2023Review
- Autoimmunity: A New Focus on Nasal Polyps.International journal of molecular sciences · 2023Review
- Bee venom as an alternative for antibiotics against Staphylococcus aureus infections.Scientific reports · 2023Article
- Gut microbiome dysbiosis in the setting of solid organ transplantation: What we have gleaned from human and animal studies.World journal of transplantation · 2022Review
- Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection.Frontiers in immunology · 2022Review
- Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch SwineFrontiers in immunology · 2022Article
- Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Alteration in the Skin Microbiome in Cutaneous Graft Versus Host Disease.Acta dermato-venereologica · 2021Article
- Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.The Journal of clinical investigation · 2021Article
- Bacterial products in donor airways prevent the induction of lung transplant tolerance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Localized mandibular infection affects remote in vivo bioreactor bone generation.Biomaterials · 2020Article
- Microbiota in organ transplantation: An immunological and therapeutic conundrum?Cellular immunology · 2020Review
- Trained immunity in organ transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Review
- Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells.Frontiers in immunology · 2020Article
- Impact of infection on transplantation tolerance.Immunological reviews · 2019Review
- Exercise increases skin graft resistance to rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Clinical correlations between bacterial infections and rejection suggest a hypothesis that innate immune stimulation by bacterial infections results in the production of inflammatory cytokine that facilitate bystander T-cell activation, increased alloreactivity and inhibition of tolerance induction. Previous studies demonstrated that IFNβ produced during an infection with a model bacterium, Listeria monocytogenes, prevented the induction of transplantation tolerance in mice with anti-CD154 and donor-specific transfusion (DST) (1). We investigated the impact of two clinically relevant bacterial infections at the time of transplantation on the ability of anti-CD154 and DST to induce skin allograft acceptance in mice. Staphylococcus aureus (SA) infection prevented skin allograft acceptance whereas maximally tolerated doses of Pseudomonas aeruginosa infection had no effect. SA induced an acute production of IL-6, which was necessary and sufficient for the prevention of skin allograft acceptance. Furthermore, a single pulse of methylprednisolone modulated IL-6 production during SA infection and facilitated skin allograft acceptance in SA-infected recipients. Taken together, our results suggest that bacterial infections elicit specific proinflammatory cytokines signatures that can serve as barriers to tolerance induction, and that inhibiting the production of or neutralizing these inflammatory cytokines can synergize with costimulatory blockade-based therapies to facilitate the development of transplantation tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.