ArticleMovement disorders : official journal of the Movement Disorder Society2011
Rate of 6-[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson's disease.Nature biotechnology · 2026Trial
- Accuracy of the Early Diagnosis of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Downregulation of microRNA-330-5p induces manic-like behaviors in REM sleep-deprived rats by enhancing tyrosine hydroxylase expression.CNS neuroscience & therapeutics · 2023Article
- Onset pattern of nigrostriatal denervation in early Parkinson's disease.Brain : a journal of neurology · 2022Article
- Comparison of Transcranial Sonography and [Movement disorders : official journal of the Movement Disorder Society · 2022Article
- The role of neuroimaging in Parkinson's disease.Journal of neurochemistry · 2021Review
- Physiological Whole-Brain Distribution of [Molecular imaging and biology · 2019Article
- Article
- [Neurotoxicology · 2018Article
- Inventory of real world data sources in Parkinson's disease.BMC neurology · 2017Review
- Anterior cingulate dopamine turnover and behavior change in Parkinson's disease.Brain imaging and behavior · 2015Article
- Early diagnosis and therapy of Parkinson's disease: can disease progression be curbed?Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
- Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates.Frontiers in aging neuroscience · 2013Article
- Resting state functional connectivity of the striatum in Parkinson's disease.Brain : a journal of neurology · 2012Article
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Authors and funding
12 authors at 4 institutions in 1 country.
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Abstract
backgroundRate of decline in 6-L-[(18)F]fluorodopa (FDOPA) uptake within the striatum has been reported as showing regional differences in Parkinson's disease (PD).
methodsWe acquired longitudinal brain FDOPA positron emission tomography (PET) studies in 26 PD subjects and 11 controls over 4.5 years. We analyzed both spatially normalized voxel-wise maps of radiotracer influx (Kocc) and average Kocc values for six non-overlapping volumes of interest (VOIs) encompassing the striatum.
resultsThe voxel-wise analysis showed that in PD, FDOPA Kocc decline spanned the striatum but was greatest in the posterior putamen ipsilateral and anterior putamen contralateral to initial symptoms. The VOI approached showed that absolute rates of Kocc decline were significantly greater in PD than control subjects, but that the slope of decline did not differ between subregions. In PD, ratios of uptake between subregions did not change during the study with the exception of the ipsilateral putamen/caudate ratio. Decline rates were marginally greater during earlier time segments. Both male gender and advancing age were associated with lower baseline FDOPA uptake, but no difference in decline rates. VOI Kocc values were significantly correlated with disease duration, but only moderately correlated with clinical measures. DISCUSSION: We conclude that FDOPA uptake in subregions of the striatum is strongly correlated with disease duration and age, and declines approximately equally from symptom onset in PD. This implies that in idiopathic PD, relative preservation of uptake in the anterior striatum reflects a delay in pathologic involvement of nigrostriatal projections to this region.
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