ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Intravascular pillars and pruning in the extraembryonic vessels of chick embryos.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Intussusceptive angiogenesis: bridging in vivo and in vitro observations.Angiogenesis · 2025Article
- Intussusceptive angiogenesis facilitated by microthrombosis has an important example in angiolipoma. An ultrastructural and immunohistochemical study.Histology and histopathology · 2023Article
- Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19.Cold Spring Harbor perspectives in medicine · 2022Review
- Comparison of the Behavior of Perivascular Cells (Pericytes and CD34+ Stromal Cell/Telocytes) in Sprouting and Intussusceptive Angiogenesis.International journal of molecular sciences · 2022Review
- COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.Angiogenesis · 2021Review
- Intussusceptive Angiogenesis and Peg-Socket Junctions between Endothelial Cells and Smooth Muscle Cells in Early Arterial Intimal Thickening.International journal of molecular sciences · 2020Article
- Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.Histology and histopathology · 2020Review
- Remodeling of the Microvasculature: May the Blood Flow Be With You.Frontiers in physiology · 2020Review
- Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development.Scientific reports · 2018Article
- Auto-fusion and the shaping of neurons and tubes.Seminars in cell & developmental biology · 2016Review
- When it is better to regress: dynamics of vascular pruning.PLoS biology · 2015Article
- Endothelial cell self-fusion during vascular pruning.PLoS biology · 2015Article
- Stretch-induced intussuceptive and sprouting angiogenesis in the chick chorioallantoic membrane.Microvascular research · 2014Article
- Intussusceptive angiogenesis: expansion and remodeling of microvascular networks.Angiogenesis · 2014Review
- Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis.Microvascular research · 2013Article
- Article
- CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.American journal of respiratory cell and molecular biology · 2012Article
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Authors and funding
8 authors.
Funding
Abstract
To investigate the local mechanical forces associated with intravascular pillars and vessel pruning, we studied the conducting vessels in the extraembryonic circulation of the chick embryo. During the development days 13-17, intravascular pillars and blood flow parameters were identified using fluorescent vascular tracers and digital time-series video reconstructions. The geometry of selected vessels was confirmed by corrosion casting and scanning electron microscopy. Computational simulations of pruning vessels suggested that serial pillars form along pre-existing velocity streamlines; blood pressure demonstrated no obvious spatial relationship with the intravascular pillars. Modeling a Reynolds number of 0.03 produced 4 pillars at approximately 20-μm intervals matching the observed periodicity. In contrast, a Reynolds number of 0.06 produced only 2 pillars at approximately 63-μm intervals. Our modeling data indicated that the combination of wall shear stress and gradient of shear predicted the location, direction, and periodicity of developing pillars.
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