ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2011
Genome-wide association mapping reveals epistasis and genetic interaction networks in sugar beet.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- An IBD-based mixed model approach for QTL mapping in multiparental populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- MIDESP: Mutual Information-Based Detection of Epistatic SNP Pairs for Qualitative and Quantitative Phenotypes.Biology · 2021Article
- Deciphering the Genetic Architecture of Plant Height in Soybean Using Two RIL Populations Sharing a CommonPlants (Basel, Switzerland) · 2019Article
- Study of QTLs linked to awn length and their relationships with chloroplasts under control and saline environments in bread wheat.Genes & genomics · 2019Article
- Modeling Epistasis in Genomic Selection.Genetics · 2015Article
- Adult plant development in triticale (× triticosecale wittmack) is controlled by dynamic genetic patterns of regulation.G3 (Bethesda, Md.) · 2014Article
- Relatedness severely impacts accuracy of marker-assisted selection for disease resistance in hybrid wheat.Heredity · 2014Article
- Cross-validation in association mapping and its relevance for the estimation of QTL parameters of complex traits.Heredity · 2014Article
- Genetic diversity and linkage disequilibrium analysis in elite sugar beet breeding lines and wild beet accessions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Dynamic quantitative trait locus analysis of seed vigor at three maturity stages in rice.PloS one · 2014Article
- Flowering time control in European winter wheat.Frontiers in plant science · 2014Article
- Article
- Identification of QTLs for seed and pod traits in soybean and analysis for additive effects and epistatic effects of QTLs among multiple environments.Molecular genetics and genomics : MGG · 2013Article
- Dissecting the genetic architecture of frost tolerance in Central European winter wheat.Journal of experimental botany · 2013Article
- Effect of inter- and intragenic epistasis on the heritability of oil content in rapeseed (Brassica napus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Detection of QTL for flowering time in multiple families of elite maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Comparison of biometrical approaches for QTL detection in multiple segregating families.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Identification of QTLs with main, epistatic and QTL × environment interaction effects for salt tolerance in rice seedlings under different salinity conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Mapping QTL for agronomic traits in breeding populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Review
- Association of single nucleotide polymorphic sites in candidate genes with aggressiveness and deoxynivalenol production in Fusarium graminearum causing wheat head blight.BMC genetics · 2012Article
Corrections and comments
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5 authors.
Funding
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Abstract
Epistasis is defined as interactions between alleles of two or more genetic loci. Detection of epistatic interactions is the key to understand the genetic architecture and gene networks underlying complex traits. Here, we examined the extent of epistasis for seven quantitative traits with an association mapping approach in a large population of elite sugar beet lines. We found that correction for population stratification is required and that in terms of reducing the false-positive rate the mixed model approach including the kinship matrix performed best. In genome-wide scans, we detected both main effects and epistatic QTL. For physiological traits, the detected digenic and higher-order epistasis explained a considerable proportion of the genotypic variance. We illustrate that the identified epistatic interactions define comprehensive genetic networks, which may serve as starting points towards a systems-oriented approach to understand the regulation of complex traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.