ArticleHistochemistry1990
Expression of myosin heavy chain isoforms in developing rat muscle spindles.
Article in Histochemistry, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Co-expression of MyHC-15 with other known isoforms in rat muscle spindles.European journal of histochemistry : EJH · 2025Article
- Fibre typing of intrafusal fibres.Journal of anatomy · 2015Review
- Intrafusal myosin heavy chain expression of human masseter and biceps muscles at young age shows fundamental similarities but also marked differences.Histochemistry and cell biology · 2013Article
- Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.The Journal of physiology · 2010Article
- Expression of Myosin heavy chain isoforms in rat soleus muscle spindles after 19 days of hypergravity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2003Article
- Origin of intrafusal fibers from a subset of primary myotubes in the rat.Anatomy and embryology · 1995Article
- An immunocytochemical marker for early type I muscle fibers in the developing rat hindlimb.Anatomy and embryology · 1995Article
- Neomyogenesis in neonatally de-efferented and postnatally denervated rat muscle spindles.Acta neuropathologica · 1995Article
- Sequences of intrafusal fiber formation are muscle-dependent in rat hindlimbs.Anatomy and embryology · 1994Article
- Development of chicken intrafusal muscle fibers.Cell and tissue research · 1993Article
- Transient expression of a slow-tonic MHC isoform by extrafusal fibers in the developing rat.Anatomy and embryology · 1993Article
- Differential effects of neonatal denervation on intrafusal muscle fibers in the rat.Anatomy and embryology · 1993Article
- Myosin isoform transitions during development of extra-ocular and masticatory muscles in the fetal rat.Anatomy and embryology · 1992Article
- Rat muscle spindle immunocytochemistry revisited.Histochemistry · 1991Article
- Aggregation of myonuclei and the spread of slow-tonic myosin immunoreactivity in developing muscle spindles.Histochemistry · 1991Article
- Slow-tonic MHC expression in paralyzed hindlimbs of fetal rats.Histochemistry · 1991Article
- Expression of an alpha cardiac-like myosin heavy chain in muscle spindle fibres.Histochemistry · 1990Article
- Influence of neonatal motor denervation on expression of myosin heavy chain isoforms in rat muscle spindles.Histochemistry · 1990Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of muscle spindles, with respect to the expression of myosin heavy chain isoforms was studied in rat hind limbs from 17 days of gestation up to seven days after birth. Serial cross-sections were labelled with antibodies against slow tonic, slow twitch and neonatal isomyosins, myomesin, laminin and neurofilament protein. At 17-18 days of gestation, a small population of primary myotubes expressing slow tonic myosin were identified as the earliest spindle primordia. These myotubes also expressed slow twitch and, to a lesser extent, neonatal myosin. At 19-20 days of gestation a second myotube became apparent; this staining strongly with anti-neonatal myosin. A day later this secondary myotube acquired reactivity to anti-slow tonic and anti-slow twitch myosins. By birth, a third myotube was present; this staining strongly with anti-neonatal myosin but otherwise unreactive with the other antibodies against myosin heavy chains. Three days after birth a fourth myotube, with identical reactivity to the third one, became apparent. Regional variation in the expression of isomyosins, which was present since birth in the two nuclear bag fibers was further enhanced: the nuclear bag staining strongly with anti-slow tonic and antineonatal in the equatorial region and with decreasing intensity towards the poles, whilst with anti-slow twitch the stainability was low in the equatorial and high in the polar region. The nuclear bag fiber showed a homogeneous staining: high with anti-slow tonic, moderate with anti-neonatal, and displayed stainability to anti-slow twitch myosin in the polar regions only. No regional variation was found along the chain fiber/myotube.(ABSTRACT TRUNCATED AT 250 WORDS)
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