ArticlePloS one2011
Soluble Flt-1 and PlGF: new markers of early pregnancy loss?
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Utility of Placental Growth Factor for the Prediction of Miscarriage in the First Trimester of Pregnancy: A Case-Control Study.International journal of women's health · 2025Article
- Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?Indian journal of clinical biochemistry : IJCB · 2024Article
- Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value.International journal of molecular sciences · 2024Article
- Biochemical markers for prediction of the first half pregnancy losses: a review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Review
- Association of serum levels of vascular endothelial growth factor and placental growth factor in early threatened abortion and premature delivery: A case‑control study.Experimental and therapeutic medicine · 2023Article
- Human Decidual CD1aInternational journal of molecular sciences · 2023Article
- Monocytes and macrophages in pregnancy: The good, the bad, and the ugly.Immunological reviews · 2022Review
- High early pregnancy body mass index is associated with alterations in first- and second-trimester angiogenic biomarkers.American journal of obstetrics & gynecology MFM · 2022Observational
- Reduced expression in preterm birth of sFLT-1 and PlGF with a high sFLT-1/PlGF ratio in extracellular vesicles suggests a potential biomarker.Frontiers in endocrinology · 2022Article
- Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type‑2 receptor upregulation.Molecular medicine reports · 2020Article
- Pregnancy complications recur independently of maternal vascular malperfusion lesions.PloS one · 2020Article
- The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study.Medicine · 2019Article
- Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.Journal of hypertension · 2019Review
- First Trimester Pregnancy Loss and the Expression of Alternatively Spliced NKp30 Isoforms in Maternal Blood and Placental Tissue.Frontiers in immunology · 2015Article
- Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.PloS one · 2015Article
- Pre-eclampsia part 1: current understanding of its pathophysiology.Nature reviews. Nephrology · 2014Review
- Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth effectors during human pregnancy.Biology of reproduction · 2014Article
- In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.PloS one · 2014Article
- A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent data have indicated a relationship between placental oxygen and angiogenic protein levels in the first trimester of normal pregnancies. Our objective was to investigate if maternal serum levels of angiogenic factors Soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1), soluble Endoglin and placental growth factor (PlGF) are altered in women with symptoms of threatened miscarriage (TM) and if they are predictive of a subsequent miscarriage. Blood samples were collected at 6-10 weeks from women presenting with TM (n = 40), from asymptomatic controls (n = 32) and from non- pregnant women in their luteal phase (n = 14). All samples were assayed for serum level of sFLT-1, PlGF, sEndoglin and HSP70 using commercial ELISAs. Samples were analysed retrospectively on the basis of pregnancy outcome. TM group included 21 women with a normal pregnancy outcome and 19 with subsequent complete miscarriage. The latter subgroup had significantly lower mean maternal serum (MS) sFlt-1 (83%, P<0.001) and PlGF (44%, P<0.001) compared to those with a normal pregnancy outcome. Asymptomatic control pregnant women had similar MS levels of sFlt-1 and PlGF compared to the TM patients with a normal outcome. The mean MS sFlt-1 (>10 fold) and MS PlGF (∼2 fold) levels were significantly (P<0.001) higher in control pregnant women compared to the non-pregnant group in the luteal phase of the menstrual cycle. Soluble Endoglin was not altered in the normal pregnant women compared to non pregnant women, although lower in the TM subgroup with a subsequent miscarriage (∼25%, P<0.001) compared to TM with a live birth. There was no significant difference in the mean MS HSP 70 levels between the different groups. This study shows that sFlt1 and PlGF MS levels are increased by several folds in early pregnancy and that MS sFlt-1 and MS PlGF are markedly decreased in threatened miscarriage patients who subsequently have a miscarriage suggesting these proteins are sensitive predictive markers of subsequent pregnancy loss.
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