ArticleInfection and immunity1990
Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 105 citations in OpenAlex.
- Review
- Epidemiology of Invasive Candidiasis.Clinical epidemiology · 2024Review
- Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages.Nature communications · 2021Article
- The Interactions BetweenFrontiers in microbiology · 2021Review
- Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms.Scientific reports · 2019Article
- Histone deacetylase inhibitor attenuates experimental fungal keratitis in mice.Scientific reports · 2019Article
- NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis.International journal of molecular sciences · 2018Article
- Fungal Recognition and Host Defense Mechanisms.Microbiology spectrum · 2017Review
- Novel nanoscale bacteriophage-based single-domain antibodies for the therapy of systemic infection caused by Candida albicans.Scientific reports · 2016Article
- The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2016Article
- Interleukin-1 function and role in rheumatic disease.Nature reviews. Rheumatology · 2016Review
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Role of Dectin-2 for host defense against systemic infection with Candida glabrata.Infection and immunity · 2014Article
- Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.Frontiers in microbiology · 2014Article
- The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.European journal of immunology · 2011Article
- Proinflammatory chemokines during Candida albicans keratitis.Experimental eye research · 2010Article
- IL-1beta processing in host defense: beyond the inflammasomes.PLoS pathogens · 2010Review
- Immune recognition of Candida albicans beta-glucan by dectin-1.The Journal of infectious diseases · 2007Article
- Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.The Journal of clinical investigation · 2006Article
- Treatment of intra-abdominal abscesses caused by Candida albicans with antifungal agents and recombinant murine granulocyte colony-stimulating factor.Antimicrobial agents and chemotherapy · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of human recombinant interleukin-1 alpha (IL-1 alpha) on a systemic candidal infection in mice under various conditions of immunosuppression was investigated. In normal mice and in mice pretreated with cyclophosphamide, hydrocortisone acetate, or sublethal total body irradiation, the outgrowth of Candida albicans in the kidney was significantly reduced by the administration of a single intraperitoneal dose of 80 ng of IL-1 (P less than 0.05). In mice treated with either cyclophosphamide or irradiation, IL-1 also significantly reduced the outgrowth of C. albicans in the spleen. The protective effect of IL-1 was present when given 24 h before injection of C. albicans but also when IL-1 was given simultaneously with or 6 h after injection of C. albicans in cyclophosphamide-treated mice. The effect of IL-1 was independent of the presence or recruitment of granulocytes, since IL-1 inhibited the outgrowth of C. albicans in the kidneys and spleens of mice that were rendered severely granulocytopenic (less than 50 granulocytes per mm3) throughout the duration of the infection by either repeated injections of cyclophosphamide or sublethal total body irradiation. These results indicate that the enhancement of host resistance by IL-1 is not due solely to increased granulocytopoiesis or chemotaxis of granulocytes but strongly suggest that other mechanisms play a role in the protective effect of IL-1 against systemic infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.