SynthesisWorld journal of gastroenterology2011
p53 codon 72 polymorphism and liver cancer susceptibility: a meta-analysis of epidemiologic studies.
Synthesis in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis.Genetics research · 2015Pooled it
- The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Tumor protein 53 gene polymorphism, demographic attributes and associated risk factors among liver cancer patients in Calabar, Nigeria.BMC cancer · 2025Article
- Global, regional, and national burden of liver cancer attributable to high BMI, 1990-2021, with future projections to 2040.Frontiers in oncology · 2025Article
- Solid Tumor Opioid Receptor Expression and Oncologic Outcomes: Analysis of the Cancer Genome Atlas and Genotype Tissue Expression Project.Frontiers in oncology · 2022Article
- TLR4 Polymorphisms and Expression in Solid Cancers.Molecular diagnosis & therapy · 2018Review
- [Clinical analyses of 50 cases of myelodysplastic syndrome with deletion of chromosome 5q].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Article
- Human genetic variation and the risk of hepatocellular carcinoma development.Hepatology international · 2013Article
- The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.Journal of liver · 2013Article
- TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients.Infectious agents and cancer · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimTo evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis.
methodsTwo investigators independently searched the Medline, Embase and Chinese Biomedicine databases. Summary odds ratios and 95% CI for p53 codon 72 polymorphism and liver cancer were calculated in fixed-effects model (Mantel-Haenszel method) and random-effects model (DerSimonian and Laird method) when appropriate.
resultsThis meta-analysis included 1115 liver cancer cases and 1778 controls. The combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer, but not between Arg/Arg or Pro/Arg genotype and liver cancer. When stratifying for race, similar results were obtained, i.e. patients with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among Asians. After stratifying the various studies by control source, gender, family history of liver cancer and chronic hepatitis virus infection, we found that (1) patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer; (2) female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer; (3) subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development; and (4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer.
conclusionThis meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.