ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2011
Analysis of mitochondrial ND1 gene in human colorectal cancer.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Mitochondrial microsatellite instability in patients with metastatic colorectal cancer.Virchows Archiv : an international journal of pathology · 2015Pooled it
- Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity.PloS one · 2015Trial
- Mitochondrial DNA Mutations in Colorectal Cancer Stem Cells: Implications for Tumor Dynamics and Therapeutic Strategies.Current medicinal chemistry · 2026Review
- Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials.Pharmaceutics · 2025Review
- Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer.Antioxidants (Basel, Switzerland) · 2024Review
- Exploring transcription modalities from bimodal, single-cell RNA sequencing data.NAR genomics and bioinformatics · 2024Article
- Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space.International journal of molecular sciences · 2024Review
- Mitochondrial complex I subunitHeliyon · 2024Review
- Roles of MT-ND1 in Cancer.Current medical science · 2023Review
- A computational study on mitogenome-encoded proteins of Pavo cristatus and Pavo muticus identifies key genetic variations with functional implications.Journal, genetic engineering & biotechnology · 2023Article
- Mitochondrial DNA Changes in Respiratory Complex I Genes in Brain Gliomas.Biomedicines · 2023Article
- Functional Role of Mitochondrial DNA in Cancer Progression.International journal of molecular sciences · 2022Review
- Quantitative detection of circulating MT-ND1 as a potential biomarker for colorectal cancer.Bosnian journal of basic medical sciences · 2021Article
- Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes.Redox biology · 2020Article
- Next-generation sequencing identifies novel mitochondrial variants in pituitary adenomas.Journal of endocrinological investigation · 2019Article
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.Genome medicine · 2017Article
- The Mitochondrial Complex(I)ty of Cancer.Frontiers in oncology · 2017Review
- Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?Disease markers · 2017Review
- Investigation of the association between mitochondrial DNA andOncology letters · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer as a mortal disease affected both sexes of all ethnic and racial human groups. Former studies have indicated some mutations in the mitochondrial DNA (mtDNA) in different human cancers. Complex I NADH has the most subunits encoded by mtDNA. For a better understanding of the mtDNA abnormality in colorectal cancer some genes of this complex is screened for existence of mutations.
methodsOne of the main regions of the mtDNA encoding protein was screened by PCR-RFLP followed by DNA sequencing. The obtained sequences were aligned with the revised Cambridge Reference Sequence (rCRS). Each alteration recorded as single nucleotide polymorphisms (SNPs), deletions or insertions.
resultsEight mutations were found in 15 samples out of 30 studied populations and no mutation detected in other 15 samples. Among these 15 mutated samples, 7 different mutations were found in 7 patients, that means one mutation per patient and the 8th mutation (T4216C) was common in the rest of 8 samples; in other words T4216C mutation in 27% of tested samples was identified (8 patients out of 30 patients). The existence of T4216C mutation was found to be significantly different (p ≤ 0.05) between tumoral patient's tissue and adjacent normal tissue.
conclusionsResults showed that a high frequency of somatic alterations of mtDNA occurs during the carcinogenesis and/or the progression of colorectal cancer. Based on the mtDNA mutation pattern observed in this study and other previously studies it is believed that looking for somatic mutations in mtDNA would be one of the diagnostic values in early detection of cancer.
Indexed as
Identifiers
21448383PMC3063429W2144491003What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.