ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2011
Enalapril improves endothelial function in patients with migraine: A randomized, double-blind, placebo-controlled trial.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Enalapril Is Superior to Lisinopril in Improving Endothelial Function without a Difference in Blood-Pressure-Lowering Effects in Newly Diagnosed Hypertensives.Biomedicines · 2023Article
- Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment.Advanced biomedical research · 2016Article
- Endothelial Function in Patients with Migraine without Aura during the Interictal Period.International journal of preventive medicine · 2015Article
- Preventive Effects of a Three-month Yoga Intervention on Endothelial Function in Patients with Migraine.International journal of preventive medicine · 2014Article
- Peripheral vascular dysfunction in migraine: a review.The journal of headache and pain · 2013Review
- Mutation analysis of CACNA1A gene in Iranian migrainous and review literatures.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case-control study.The journal of headache and pain · 2013Article
- Efficacy of Enalapril in Migraine Prophylaxis: A Randomized, Double-blind, Placebo-controlled Trial.International journal of preventive medicine · 2013Article
- Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are increasing evidences of endothelial dysfunction in migraine. The ACE-inhibitors have previously been shown to be effective in migraine prophylaxis. Furthermore, ACE inhibitors have beneficial effects on endothelial dysfunction. We therefore investigated whether Enalapril is effective in endothelial function improvement.
methodsIn this randomized clinical trial, 10 mg Enalapril daily was compared with matched placebo in 40 patients with migraine for two months. Flow Mediated Dilation (FMD), serum total nitrite and C-reactive protein (CRP) were measured in all patients at the baseline and after 2 months.
resultspatients' FMD increased in the case group after treatment with Enalapril (p = 0.002) while there was no significant change in control group. Total nitrite concentration increased in case group (p = 0.000), while there was no significant difference before treatment. There was no significant difference in the CRP concentrations in two groups.
conclusionsThese results indicate that ACE inhibition can improve endothelial function in patients with migraine, as it has been shown by both FMD and serum levels of nitric oxide. The mechanism could be either that Enalapril limits the angiotensin IIinduced production of superoxide radicals which would normally inactivate nitric oxide, or that it may increase bradykinin-mediated nitric oxide release.
Indexed as
Identifiers
21448379PMC3063439W2110302023What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.