ArticleInternational journal of biological sciences2011
Numb protects renal proximal tubular cells from puromycin aminonucleoside-induced apoptosis through inhibiting Notch signaling pathway.
Article in International journal of biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- From Single-Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Puerarin alleviates cisplatin-induced acute renal damage and upregulates microRNA-31-related signaling.Experimental and therapeutic medicine · 2020Article
- Salvia przewalskii extract of total phenolic acids inhibit TLR4 signaling activation in podocyte injury induced by puromycin aminonucleoside in vitro.Renal failure · 2018Article
- Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.Cell death & disease · 2018Article
- Increased Numb protein expression predicts poor clinical outcomes in esophageal squamous cell carcinoma patients.Cancer biology & therapy · 2018Article
- Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure.The Journal of biological chemistry · 2017Article
- Numb/Notch signaling pathway modulation enhances human pancreatic cancer cell radiosensitivity.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M.Oncotarget · 2016Article
- Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.Cell death & disease · 2014Article
- The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma.Oncotarget · 2014Article
- Induction of mitochondrial dependent apoptosis and cell cycle arrest in human promyelocytic leukemia HL-60 cells by an extract from Dorstenia psilurus: a spice from Cameroon.BMC complementary and alternative medicine · 2013Article
- LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile.Journal of cell communication and signaling · 2013Article
- Numb/Notch signaling plays an important role in cerebral ischemia-induced apoptosis.Neurochemical research · 2013Article
- Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.International journal of biological sciences · 2012Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numb was originally discovered as an intrinsic cell fate determinant in Drosophila by antagonizing Notch signaling. The present study is to characterize the role of Numb in oxidative stress-induced apoptosis of renal proximal tubular cells. Exposure of NRK52E cells to puromycin aminonucleoside (PA) resulted in caspase 3-dependent apoptosis. Numb expression was downregulated by PA in a time- and dose-dependent manner. Knocking down endogenous Numb by siRNA sensitized NRK52E cells to PA-induced apoptosis, whereas overexpressing Numb protected NRK52E cells from PA-induced apoptosis. Moreover, PA activated Notch signaling in a time- and dose-dependent manner as indicated by increased expression of the intracellular domain of Notch and Hes-1. Notch signaling inhibitor DAPT significantly attenuated Numb siRNA-augmented apoptosis. On the other hand, overexpression of intracellular domain of Notch1 could reverse the protective effect of Numb on PA-induced apoptosis. Taken together, our data demonstrated that, in renal proximal tubular cells, Numb functions as a protective molecule on PA-induced apoptosis through antagonizing Notch signaling activity.
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